{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:19:46Z","timestamp":1778062786973,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jaip.2026.02.013","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:15:32Z","timestamp":1771892132000},"page":"1113-1120.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Long-Term Hypothalamic-Pituitary-Adrenal-Axis Suppression After Maintenance Oral Corticosteroid Withdrawal in Severe Asthma: Biochemical Assessment Is Essential"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0729-5926","authenticated-orcid":false,"given":"Liam Michael","family":"Coyle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela Jane","family":"McDowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlene","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire Ann","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam Gabriel","family":"Heaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2026.02.013_bib1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jaci.2014.08.042","article-title":"The prevalence of severe refractory asthma","volume":"135","author":"Hekking","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.02.013_bib2","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.chest.2019.10.053","article-title":"Characterization of severe asthma worldwide: data from the International Severe Asthma Registry","volume":"157","author":"Wang","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2026.02.013_bib3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/thoraxjnl-2017-210531","article-title":"Healthcare resource use and costs of severe, uncontrolled eosinophilic asthma in the UK general population","volume":"73","author":"Kerkhof","year":"2018","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2026.02.013_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1164\/rccm.201904-0903SO","article-title":"Systematic literature review of systemic corticosteroid use for asthma management","volume":"201","author":"Bleecker","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2026.02.013_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12931-018-0742-y","article-title":"Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis","volume":"19","author":"Bloechliger","year":"2018","journal-title":"Respir Res"},{"key":"10.1016\/j.jaip.2026.02.013_bib6","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1210\/jc.2015-1218","article-title":"Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis","volume":"100","author":"Broersen","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jaip.2026.02.013_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/JAA.S176026","article-title":"Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study","volume":"11","author":"Price","year":"2018","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.jaip.2026.02.013_bib8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jaip.2024.10.024","article-title":"Longitudinal assessment of glucocorticoid toxicity reduction in patients with severe asthma treated with biologic therapies","volume":"13","author":"McDowell","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.02.013_bib9","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S1081-1206(10)61758-9","article-title":"Oral corticosteroid-sparing effects of inhaled corticosteroids in the treatment of persistent and acute asthma","volume":"92","author":"Ververeli","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2026.02.013_bib10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/cea.13561","article-title":"Matching-adjusted comparison of oral corticosteroid reduction in asthma: systematic review of biologics","volume":"50","author":"Bourdin","year":"2020","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2026.02.013_bib11","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1210\/clinem\/dgae250","article-title":"European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: diagnosis and therapy of glucocorticoid-induced adrenal insufficiency","volume":"109","author":"Beuschlein","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jaip.2026.02.013_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1510433","article-title":"Clinical characteristics of adrenal crisis in 371 adult patients with glucocorticoid-induced adrenal insufficiency","volume":"15","author":"Qiu","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jaip.2026.02.013_bib13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/jama.2025.5485","article-title":"Adrenal insufficiency in adults: a review","volume":"334","author":"Vaidya","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2026.02.013_bib14","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1164\/rccm.202007-2721OC","article-title":"Expert consensus on the tapering of oral corticosteroids for the treatment of asthma. A Delphi study","volume":"203","author":"Suehs","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2026.02.013_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S2213-2600(21)00352-0","article-title":"Oral corticosteroid elimination via a personalised reduction algorithm in adults with severe, eosinophilic asthma treated with benralizumab (PONENTE): a multicentre, open-label, single-arm study","volume":"10","author":"Menzies-Gow","year":"2022","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2026.02.013_bib16","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02273-2019","article-title":"Prevalence and recovery of adrenal insufficiency in steroid-dependent asthma patients receiving biologic therapy","volume":"56","author":"Nanzer","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2026.02.013_bib17","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.jaip.2025.03.048","article-title":"Assessment of an oral corticosteroid withdrawal pathway for severe asthma patients receiving biologic therapies","volume":"13","author":"Aung","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.02.013_bib18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/thoraxjnl-2020-215168","article-title":"Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era","volume":"76","author":"Jackson","year":"2021","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2026.02.013_bib19","series-title":"R: a language and environment for statistical computing","year":"2025"},{"key":"10.1016\/j.jaip.2026.02.013_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212259","article-title":"Clinical indicators of adrenal insufficiency following discontinuation of oral glucocorticoid therapy: a Danish population-based self-controlled case series analysis","volume":"14","author":"Laugesen","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2026.02.013_bib21","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1210\/jc.2019-00153","article-title":"Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England","volume":"104","author":"Mebrahtu","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jaip.2026.02.013_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.897211","article-title":"Daily glucocorticoid replacement dose in adrenal insufficiency, a mini review","volume":"13","author":"Caetano","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jaip.2026.02.013_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/cen.15077","article-title":"Diagnostic accuracy of morning serum cortisol concentration in confirming recovery of the hypothalamic-pituitary-adrenal axis in patients on chronic glucocorticoid therapy","volume":"101","author":"Sharma","year":"2024","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jaip.2026.02.013_bib24","article-title":"Position statement on the use of synthetic ACTH (Synacthen) in patients with a history of asthma","author":"Tomlinson","year":"2020","journal-title":"Society for Endocrinology"},{"key":"10.1016\/j.jaip.2026.02.013_bib25","doi-asserted-by":"crossref","first-page":"00009","DOI":"10.1183\/23120541.00009-2019","article-title":"Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONTENTE Trial","volume":"5","author":"Menzies-Gow","year":"2019","journal-title":"ERJ Open Res"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219826001510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219826001510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:06:19Z","timestamp":1778061979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219826001510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2213219826001510"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2026.02.013","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistent Long-Term Hypothalamic-Pituitary-Adrenal-Axis Suppression After Maintenance Oral Corticosteroid Withdrawal in Severe Asthma: Biochemical Assessment Is Essential","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2026.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}