{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:14:51Z","timestamp":1790118891982,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jaip.2026.05.038","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:46:40Z","timestamp":1788774400000},"page":"1989-1997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Approach to Urticaria and Angioedema in the Older Patient"],"prefix":"10.1016","volume":"14","author":[{"given":"Tukisa","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossi","family":"Rosman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchita","family":"Paranthaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Gobert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2026.05.038_bib1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11882-023-01117-7","article-title":"Biomarkers of autoimmune chronic spontaneous urticaria","volume":"23","author":"Larenas-Linnemann","year":"2023","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2026.05.038_bib2","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jaci.2020.03.005","article-title":"The role of eosinophils in chronic spontaneous urticaria","volume":"145","author":"Altrichter","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jaip.2018.04.013","article-title":"Chronic spontaneous urticaria: the devil\u2019s itch","volume":"6","author":"Saini","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib4","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/all.15090","article-title":"The international EAACI\/GA2LEN\/EuroGuiDerm\/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria","volume":"77","author":"Zuberbier","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.05.038_bib5","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1016\/S2666-7568(23)00088-0","article-title":"Representative enrolment of older adults in clinical trials: the time is now","volume":"4","author":"Schwartz","year":"2023","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.jaip.2026.05.038_bib6","article-title":"Aging of the blood-brain barrier and altered permeability to peripheral immune cells: implications for central nervous system disorders","author":"Gu","year":"2026","journal-title":"Aging Dis"},{"key":"10.1016\/j.jaip.2026.05.038_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/cpt.2452","article-title":"Roadmap to 2030 for drug evaluation in older adults","volume":"112","author":"Liu","year":"2022","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jaip.2026.05.038_bib8","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jaip.2022.12.041","article-title":"Chronic urticaria in elderly\u2014new insights","volume":"11","author":"Khaliliya","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s40266-023-01010-y","article-title":"Chronic urticaria in older adults: treatment considerations","volume":"40","author":"Patruno","year":"2023","journal-title":"Drugs Aging"},{"key":"10.1016\/j.jaip.2026.05.038_bib10","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.jaip.2020.03.030","article-title":"Urticaria and angioedema across the ages","volume":"8","author":"Saini","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jaad.2019.02.064","article-title":"Prevalence estimates for chronic urticaria in the United States: a sex- and age-adjusted population analysis","volume":"81","author":"Wertenteil","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaip.2026.05.038_bib12","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/bjd.14470","article-title":"Epidemiology of chronic spontaneous urticaria: results from a nationwide, population-based study in Italy","volume":"174","author":"Lapi","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2026.05.038_bib13","first-page":"214","article-title":"Epidemiology of urticaria in Spain","volume":"14","author":"Gaig","year":"2004","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib14","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v101.737","article-title":"Chronic urticaria: a Swedish Registry-based cohort study on population, comorbidities and treatment characteristics","volume":"102","author":"Tayefi","year":"2022","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaip.2026.05.038_bib15","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2147\/JAA.S379912","article-title":"Prevalence, clinical manifestations, treatment, and clinical course of chronic urticaria in elderly: a systematic review","volume":"15","author":"Kulthanan","year":"2022","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.jaip.2026.05.038_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3390\/jcm10020247","article-title":"Prevalence of chronic inducible urticaria in elderly patients","volume":"10","author":"Napolitano","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jaip.2026.05.038_bib17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5114\/ada.2019.84594","article-title":"Clinical characteristics and epidemiology of chronic urticaria: a nationwide, multicentre study on 1091 patients","volume":"36","author":"Jankowska-Konsur","year":"2019","journal-title":"Postepy Dermatol Alergol"},{"key":"10.1016\/j.jaip.2026.05.038_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/hel.12010","article-title":"Chronic urticaria can be triggered by eradication of Helicobacter pylori","volume":"18","author":"Magen","year":"2013","journal-title":"Helicobacter"},{"key":"10.1016\/j.jaip.2026.05.038_bib19","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1016\/j.jaip.2023.06.033","article-title":"Chronic urticaria and angioedema: masqueraders and misdiagnoses","volume":"11","author":"Bernstein","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib20","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.jaad.2025.01.086","article-title":"Bullous pemphigoid: a practical approach to diagnosis and management in the modern era","volume":"92","author":"Powers","year":"2025","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaip.2026.05.038_bib21","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/jdv.20313","article-title":"Bullous pemphigoid burden of disease, management and unmet therapeutic needs","volume":"39","author":"Werth","year":"2025","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaip.2026.05.038_bib22","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.jaci.2022.02.007","article-title":"Urticarial vasculitis: clinical and laboratory findings with a particular emphasis on differential diagnosis","volume":"149","author":"Marzano","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s40257-024-00902-y","article-title":"Managing urticarial vasculitis: a clinical decision-making algorithm based on expert consensus","volume":"26","author":"Rothermel","year":"2025","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jaip.2026.05.038_bib24","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jaad.2022.10.052","article-title":"Clinical and pathological features of cutaneous manifestations in VEXAS syndrome","volume":"88","author":"Zakine","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaip.2026.05.038_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12016-025-09056-z","article-title":"Neutrophilic urticarial dermatosis: a window into systemic inflammation and autoimmune disorders","volume":"68","author":"Cai","year":"2025","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib26","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/all.12129","article-title":"Schnitzler\u2019s syndrome: diagnosis, treatment, and follow-up","volume":"68","author":"Simon","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.05.038_bib27","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1161\/HYPERTENSIONAHA.108.110270","article-title":"Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors","volume":"51","author":"Miller","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.jaip.2026.05.038_bib28","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.amjcard.2011.11.014","article-title":"Angiotensin-converting enzyme (ACE) inhibitor angioedema: the silent epidemic","volume":"109","author":"Roberts","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jaip.2026.05.038_bib29","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.jaip.2025.05.060","article-title":"Risk for angioedema with the use of dipeptidyl peptidase 4 inhibitors: a population-based cohort study","volume":"13","author":"Hong","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib30","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1056\/NEJMoa1312524","article-title":"A randomized trial of icatibant in ACE-inhibitor-induced angioedema","volume":"372","author":"Ba\u015f","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaip.2026.05.038_bib31","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jaip.2020.08.052","article-title":"The Importance of complement testing in acquired angioedema related to angiotensin-converting enzyme inhibitors","volume":"9","author":"Balla","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2023.100809","article-title":"Over diagnosis of bradykinin angioedema in patients treated with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers","volume":"16","author":"Douillard","year":"2023","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaip.2026.05.038_bib33","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000004363","article-title":"A nationwide study of acquired C1-inhibitor deficiency in France: characteristics and treatment responses in 92 patients","volume":"95","author":"Gobert","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaip.2026.05.038_bib34","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/bjh.13908","article-title":"High prevalence of splenic marginal zone lymphoma among patients with acquired C1 inhibitor deficiency","volume":"172","author":"Castelli","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaip.2026.05.038_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2500\/aap.2022.43.220043","article-title":"Longitudinal experience with treatment of acquired angioedema using tranexamic acid","volume":"43","author":"Kesh","year":"2022","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2026.05.038_bib36","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jaip.2023.10.017","article-title":"Efficacy and safety of rituximab-based treatments in angioedema with acquired C1-inhibitor deficiency","volume":"12","author":"Kalmi","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/1346-8138.14075","article-title":"Epidemiology and comorbidities of patients with chronic urticaria in Korea: a Nationwide population-based study","volume":"45","author":"Kim","year":"2018","journal-title":"J Dermatol"},{"key":"10.1016\/j.jaip.2026.05.038_bib38","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/cea.70094","article-title":"Lifetime age-stratified associations of comorbidities in chronic urticaria: a claims-based study of 35,907 cases","volume":"55","author":"Ha","year":"2025","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2026.05.038_bib39","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jaci.2024.11.036","article-title":"Mortality in adult patients with chronic spontaneous urticaria: a real-world cohort study","volume":"155","author":"Kolkhir","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib40","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3904\/kjim.2014.29.6.800","article-title":"Clinical features of elderly chronic urticaria","volume":"29","author":"Ban","year":"2014","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.jaip.2026.05.038_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13223-021-00637-z","article-title":"Impact of comorbidities on risk of angioedema without urticaria in elderly patients","volume":"17","author":"Bo\u017cek","year":"2021","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib42","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/jama.2024.15568","article-title":"Chronic spontaneous urticaria: a review","volume":"332","author":"Kolkhir","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2026.05.038_bib43","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/bjd.19561","article-title":"The global burden of chronic urticaria for the patient and society","volume":"184","author":"Gon\u00e7alo","year":"2021","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2026.05.038_bib44","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/jdv.20772","article-title":"Prevalence, treatment and burden of chronic spontaneous urticaria in five European countries","volume":"39","author":"Balp","year":"2025","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaip.2026.05.038_bib45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaci.2023.05.009","article-title":"Itch in elderly patients: origin, diagnostics, management","volume":"152","author":"Steinhoff","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib46","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1111\/all.70210","article-title":"The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria","volume":"81","author":"Zuberbier","year":"2026","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.05.038_bib47","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jaci.2024.05.026","article-title":"Leukotriene receptor antagonists as add-on therapy to antihistamines for urticaria: systematic review and meta-analysis of randomized clinical trials","volume":"154","author":"Rayner","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib48","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jaip.2023.03.010","article-title":"Psychiatric adverse effects of montelukast\u2014a nationwide cohort study","volume":"11","author":"Jordan","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1710-1492-9-30","article-title":"A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib50","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1159\/000530494","article-title":"Long-term omalizumab in elderly patients with chronic urticaria: is it a safe therapy?","volume":"184","author":"Narv\u00e1ez-Fern\u00e1ndez","year":"2023","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib51","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000491530","article-title":"Omalizumab updosing for better disease control in chronic spontaneous urticaria","volume":"177","author":"Kocat\u00fcrk","year":"2018","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.05.038_bib52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jaci.2024.01.028","article-title":"Dupilumab in patients with chronic spontaneous urticaria (LIBERTY-CSU CUPID): two randomized, double-blind, placebo-controlled, phase 3 trials","volume":"154","author":"Maurer","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.05.038_bib53","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s40257-021-00597-5","article-title":"Effectiveness and safety of long-term dupilumab treatment in elderly patients","volume":"22","author":"Patruno","year":"2021","journal-title":"Am J Clin Dermatol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219826005155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219826005155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:19:12Z","timestamp":1788776352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219826005155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2213219826005155"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2026.05.038","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Approach to Urticaria and Angioedema in the Older Patient","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2026.05.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}