{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:10:05Z","timestamp":1788779405856,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010385","name":"CK-CARE AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jaip.2026.06.032","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:34:20Z","timestamp":1783035260000},"page":"2115-2125.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiplex Cytokine LTT Reveals Strong T-Cell Responses to Multiple Drugs in NIDHR-Associated Multiple Drug Hypersensitivity"],"prefix":"10.1016","volume":"14","author":[{"given":"Lester","family":"Thoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gschwend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Meier-Schiesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner J.","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Hausmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Radonjic-Hoesli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-0737","authenticated-orcid":false,"given":"Daniel","family":"Yerly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Joerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2026.06.032_bib1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaip.2022.02.004","article-title":"Drug-induced hypersensitivity syndrome (DIHS)\/drug reaction with eosinophilia and systemic symptoms (DRESS): clinical features and pathogenesis","volume":"10","author":"Hama","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.06.032_bib2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/bjd.12501","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study","volume":"169","author":"Kardaun","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2026.06.032_bib3","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1365-2133.2007.07807.x","article-title":"The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations","volume":"156","author":"Shiohara","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2026.06.032_bib4","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jaip.2025.02.019","article-title":"Diagnosing and managing drug reaction with eosinophilia and systemic symptoms (DRESS) amidst remaining uncertainty","volume":"13","author":"Lee","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.06.032_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.18176\/jiaci.0220","article-title":"Overlap between DRESS syndrome and exanthema induced by sulfadiazine in a patient treated with sulfamethoxazole: utility of the lymphocyte transformation test for identification of the culprit drug","volume":"28","author":"Monge-Ortega","year":"2018","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2026.06.032_bib6","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/bjd.14704","article-title":"Overlap between maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms among cutaneous adverse drug reactions in a dermatology ward","volume":"175","author":"Pinto Gouveia","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2026.06.032_bib7","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1016\/j.jaip.2024.06.047","article-title":"Delayed skin testing for systemic medications: helpful or not?","volume":"12","author":"Barbaud","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.06.032_bib8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/bjd.12125","article-title":"A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions","volume":"168","author":"Barbaud","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2026.06.032_bib9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.alit.2025.09.004","article-title":"The Cyto-LTT: a multiplex cytokine assay to detect and assess the strength of T cell reactivity in drug hypersensitivity","volume":"75","author":"Peyer","year":"2026","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2026.06.032_bib10","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3390\/biom11060847","article-title":"Chemokines in severe cutaneous adverse reactions (SCARs)","volume":"11","author":"Miyagawa","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jaip.2026.06.032_bib11","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.jid.2020.11.027","article-title":"Granulysin-based lymphocyte activation test for evaluating drug causality in antiepileptics-induced severe cutaneous adverse reactions","volume":"141","author":"Chu","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaip.2026.06.032_bib12","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1346-8138.2010.01142.x","article-title":"Drug hypersensitivity: flare-up reactions, cross-reactivity and multiple drug hypersensitivity","volume":"38","author":"Pichler","year":"2011","journal-title":"J Dermatol"},{"key":"10.1016\/j.jaip.2026.06.032_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000458725","article-title":"Multiple drug hypersensitivity","volume":"172","author":"Pichler","year":"2017","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.06.032_bib14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/all.12350","article-title":"International Consensus on drug allergy","volume":"69","author":"Demoly","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1398-9995.2011.02720.x","article-title":"Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells","volume":"67","author":"Daubner","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib16","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaip.2019.06.009","article-title":"Multiple drug hypersensitivity syndrome in a large database","volume":"8","author":"Landry","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.06.032_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13601-020-00359-2","article-title":"Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS)","volume":"10","author":"J\u00f6rg","year":"2020","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib18","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/jdv.12419","article-title":"Recurrence of drug-induced reactions in DRESS patients","volume":"29","author":"Picard","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaip.2026.06.032_bib19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/all.12142","article-title":"Skin test concentrations for systemically administered drugs -- an ENDA\/EAACI Drug Allergy Interest Group position paper","volume":"68","author":"Brockow","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fmed.2020.00156","article-title":"Intradermal tests with drugs: an approach to standardization","volume":"7","author":"Barbaud","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jaip.2026.06.032_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.0105-4538.2001.00001.x-i8","article-title":"General considerations for skin test procedures in the diagnosis of drug hypersensitivity","volume":"57","author":"Brockow","year":"2002","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib22","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1398-9995.2004.00547.x","article-title":"The lymphocyte transformation test in the diagnosis of drug hypersensitivity","volume":"59","author":"Pichler","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1398-9995.2007.01516.x","article-title":"CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity","volume":"63","author":"Beeler","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jaip.2022.09.011","article-title":"Utility and safety of skin tests in drug reaction with eosinophilia and systemic symptoms (DRESS): a systematic review","volume":"11","author":"Teo","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.06.032_bib25","first-page":"1","article-title":"Patch testing in drug reaction with eosinophilia and systemic symptoms (DRESS): a literature review","author":"de Groot","year":"2022","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jaip.2026.06.032_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/2045-7022-4-S3-P136","article-title":"Skin tests may induce DRESS relapse","volume":"4","author":"Said","year":"2014","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.alit.2025.08.003","article-title":"Undressing DReSS as p-i mediated disease","volume":"75","author":"Pichler","year":"2026","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2026.06.032_bib28","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/j.1398-9995.2009.01985.x","article-title":"Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-g in patients with delayed-type drug hypersensitivity","volume":"64","author":"Lochmatter","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib29","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/all.14146","article-title":"The role of drug, dose, and the tolerance\/intolerance of new drugs in multiple drug hypersensitivity syndrome","volume":"75","author":"J\u00f6rg","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.06.032_bib30","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/jdv.14890","article-title":"The measurement of drug-induced interferon g-releasing cells and lymphocyte proliferation in severe cutaneous adverse reactions","volume":"32","author":"Suthumchai","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaip.2026.06.032_bib31","first-page":"236","article-title":"Serum IFN-\u03b3-inducible chemokines CXCL9 and CXCL10 are elevated in non-immediate drug hypersensitivity reactions","volume":"34","author":"Wang","year":"2016","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.06.032_bib32","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1016\/j.jaip.2025.05.056","article-title":"Utility of IFN-g enzyme-linked immunospot as adjunctive diagnostic for severe T cell\u2013mediated reactions to cotrimoxazole in high HIV and tuberculosis settings","volume":"13","author":"Selim","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.06.032_bib33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jaci.2018.10.030","article-title":"Controversies in drug allergy: testing for delayed reactions","volume":"143","author":"Phillips","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.06.032_bib34","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.alit.2025.03.007","article-title":"Recent advances in the diagnosis and treatment of DIHS\/DRESS in 2025","volume":"74","author":"Mizukawa","year":"2025","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2026.06.032_bib35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/1346-8138.12770","article-title":"Sequelae in 145 patients with drug-induced hypersensitivity syndrome\/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR)","volume":"42","author":"Kano","year":"2015","journal-title":"J Dermatol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219826005301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219826005301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:20:51Z","timestamp":1788776451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219826005301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2213219826005301"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2026.06.032","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiplex Cytokine LTT Reveals Strong T-Cell Responses to Multiple Drugs in NIDHR-Associated Multiple Drug Hypersensitivity","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2026.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}