{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:33:29Z","timestamp":1793259209779,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006544","name":"Ministry of Health, State of Israel","doi-asserted-by":"publisher","award":["Kamea grant"],"award-info":[{"award-number":["Kamea grant"]}],"id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jaip.2026.08.041","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:25:30Z","timestamp":1789662330000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rate and Predictors of Hazelnut Cross-Desensitization Following Walnut Oral Immunotherapy (Nut CRACKER Study)"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-8143","authenticated-orcid":false,"given":"Arnon","family":"Elizur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Koren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Appel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Nachshon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matan","family":"Elkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limor","family":"Ben-Nun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Mattsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Holmqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Lidholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2026.08.041_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/all.13353","article-title":"NUT Co Reactivity - ACquiring Knowledge for Elimination Recommendations (NUT CRACKER) study","volume":"73","author":"Elizur","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.08.041_bib2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11882-015-0555-8","article-title":"The prevalence of tree nut allergy: a systematic review","volume":"15","author":"McWilliam","year":"2015","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2026.08.041_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1067\/mai.2001.112031","article-title":"Fatalities due to anaphylactic reactions to foods","volume":"107","author":"Bock","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/all.13319","article-title":"EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy","volume":"73","author":"Pajno","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.08.041_bib5","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa1812856","article-title":"AR101 Oral Immunotherapy for Peanut Allergy","volume":"379","author":"Vickery","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaip.2026.08.041_bib6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S2352-4642(19)30029-X","article-title":"Walnut oral immunotherapy for desensitisation of walnut and additional tree nut allergies (Nut CRACKER): a single-centre, prospective cohort study","volume":"3","author":"Elizur","year":"2019","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.jaip.2026.08.041_bib7","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1111\/all.15212","article-title":"Cashew oral immunotherapy for desensitizing cashew-pistachio allergy (NUT CRACKER study)","volume":"77","author":"Elizur","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.08.041_bib8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.jaip.2024.12.041","article-title":"Hazelnut oral immunotherapy desensitizes hazelnut but not other tree nut allergies (Nut CRACKER Study)","volume":"13","author":"Elizur","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.08.041_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2019.10.045","article-title":"Oral immunotherapy for hazelnut allergy: a single-center retrospective study on 100 patients","volume":"8","author":"Moraly","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.08.041_bib10","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.anai.2022.01.002","article-title":"Real-life experience with hazelnut oral immunotherapy","volume":"128","author":"Sabouraud","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib11","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jaip.2026.01.024","article-title":"Real-world effectiveness analysis of preschool cashew and walnut oral immunotherapy","volume":"14","author":"Horwitz","year":"2026","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.08.041_bib12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jaip.2020.07.034","article-title":"Patient characteristics and risk factors for home epinephrine-treated reactions during oral immunotherapy for food allergy","volume":"9","author":"Nachshon","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.08.041_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jaip.2021.10.070","article-title":"Advances, practical implementation, and unmet needs regarding oral immunotherapy for food allergy","volume":"10","author":"Perrett","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.08.041_bib14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jaip.2018.06.016","article-title":"Quality of life of food-allergic patients before, during, and after oral immunotherapy","volume":"7","author":"Epstein-Rigbi","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2026.08.041_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1710-1492-10-1","article-title":"Safety and feasibility of oral immunotherapy to multiple allergens for food allergy","volume":"10","author":"B\u00e9gin","year":"2014","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S2468-1253(17)30392-8","article-title":"Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial","volume":"3","author":"Andorf","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jaip.2026.08.041_bib17","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1056\/NEJMoa2312382","article-title":"Omalizumab for the treatment of multiple food allergies","volume":"390","author":"Wood","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaip.2026.08.041_bib18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/pai.12914","article-title":"Long-term outcome of peanut oral immunotherapy\u2014real-life experience","volume":"29","author":"Nachshon","year":"2018","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0140-6736(21)02390-4","article-title":"Immune Tolerance Network. Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study","volume":"399","author":"Jones","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2026.08.041_bib20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000492399","article-title":"Evidence of cross-reactivity between different seed storage proteins from hazelnut (Corylus avellana) and walnut (Juglans regia) using recombinant allergen proteins","volume":"178","author":"Villalta","year":"2019","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib21","doi-asserted-by":"crossref","first-page":"18162","DOI":"10.1021\/acs.jafc.4c03603","article-title":"Walnut Jug r 1 is responsible for primary sensitization among patients suffering walnut-hazelnut 2S albumin cross-reactivity","volume":"72","author":"Castromil-Benito","year":"2024","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jaip.2026.08.041_bib22","first-page":"1260","article-title":"Standardizing double-blind, placebo-controlled oral food challenge: American Academy of Allergy","volume":"130","author":"Sampson","year":"2012","journal-title":"Asthma & Immunology\u2014European Academy of Allergy and Clinical Immunology PRACTALL consensus report J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib23","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1398-9995.2004.00466.x","article-title":"Standardization of food challenges in patients with immediate reactions to foods--position paper from the European Academy of Allergology and Clinical Immunology","volume":"59","author":"Bindslev-Jensen","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.08.041_bib24","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/pai.12961","article-title":"Quantitative risk reduction through peanut immunotherapy: safety benefits of an increased threshold in Europe","volume":"29","author":"Remington","year":"2018","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S2352-4642(22)00006-2","article-title":"Probiotic peanut oral immunotherapy versus oral immunotherapy and placebo in children with peanut allergy in Australia (PPOIT- 003): a multicentre, randomised, phase 2b trial","volume":"6","author":"Loke","year":"2022","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.jaip.2026.08.041_bib26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/all.16451","article-title":"Allergen-specific IgE is a stronger predictor of remission following peanut oral immunotherapy than age in children aged 1-10 years","volume":"80","author":"Ashley","year":"2025","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2026.08.041_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaci.2025.04.019","article-title":"Food allergy endotypes revisited","volume":"156","author":"Baker","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/cea.13824","article-title":"Mechanisms of oral immunotherapy","volume":"51","author":"Barshow","year":"2021","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2026.08.041_bib29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/imr.13386","article-title":"IgE versus IgG and IgA: differential roles of allergen-specific antibodies in sensitization, tolerization, and treatment of allergies","volume":"328","author":"Knol","year":"2024","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaip.2026.08.041_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/pai.13110","article-title":"Allergen components in diagnosing childhood hazelnut allergy: systematic literature review and meta-analysis","volume":"31","author":"Nilsson","year":"2020","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib31","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/cea.13163","article-title":"Tree nut allergies: allergen homology, cross-reactivity, and implications for therapy","volume":"48","author":"Smeekens","year":"2018","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2026.08.041_bib32","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1016\/j.molimm.2009.06.020","article-title":"Linear IgE-epitope mapping and comparative structural homology modeling of hazelnut and English walnut 11S globulins","volume":"46","author":"Robotham","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib33","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.molimm.2007.09.014","article-title":"Vicilin allergens of peanut and tree nuts (walnut, hazelnut and cashew nut) share structurally related IgE-binding epitopes","volume":"45","author":"Barre","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaip.2026.08.041_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jaip.2019.08.038","article-title":"Clinical and molecular characterization of walnut and pecan allergy (NUT CRACKER Study)","volume":"8","author":"Elizur","year":"2020","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219826007774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219826007774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:04:45Z","timestamp":1793257485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219826007774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"alternative-id":["S2213219826007774"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2026.08.041","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rate and Predictors of Hazelnut Cross-Desensitization Following Walnut Oral Immunotherapy (Nut CRACKER Study)","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2026.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}