{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:52:37Z","timestamp":1790632357659,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,20]],"date-time":"2007-09-20T00:00:00Z","timestamp":1190246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010658","name":"St. Paul's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>New developments in molecular genetics have improved our understanding on a number of neurodegenerative dementias considerably, especially Alzheimer's disease and frontotemporal dementia. However, this explosion of information can be overwhelming to clinicians, making it difficult to integrate into regular clinical practice. In this article, we briefly reviewed our current understanding regarding causative genetic mutations and genetic risk factors on the major forms of dementia, which provided the background information for discussion in the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia. The principles of genetic counselling were applied. Guidelines and recommendations on the application of genetics in the assessment, diagnosis, and management of patients and families with dementia were summarized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2007.07.010","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T07:21:05Z","timestamp":1192173665000},"page":"418-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Genetics and dementia: Risk factors, diagnosis, and management"],"prefix":"10.1002","volume":"3","author":[{"given":"Ging\u2010Yuek Robin","family":"Hsiung","sequence":"first","affiliation":[{"name":"Division of Neurology University of British Columbia Vancouver BC Canada"},{"name":"Brain Research Centre University of British Columbia Vancouver BC Canada"},{"name":"St. Paul's Hospital Providence Health Care Center Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dessa Sadovnick","sequence":"additional","affiliation":[{"name":"Brain Research Centre University of British Columbia Vancouver BC Canada"},{"name":"Department of Medical Genetics University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,20]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2003.11.018"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-004-0052-6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-005-0444-3"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70223-4"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988705281883"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/153331750502000408"},{"key":"e_1_2_11_8_2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1001\/archneur.55.10.1287","article-title":"The Human Genome Project: applications in the diagnosis and treatment of neurologic disease","volume":"55","author":"Evans G.A.","year":"1998","journal-title":"Arch Neurol"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017120"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_2_11_11_2","unstructured":"L.Bertram M.McQueen K.Mullin D.Blacker R.Tanzi.The AlzGene Database: Alzheimer Research Forum..2006 Available at:http:\/\/www.alzgene.org. 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