{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:34:01Z","timestamp":1790836441889,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T00:00:00Z","timestamp":1252540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010AG028377"],"award-info":[{"award-number":["P30\u2010AG028377"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AG23770"],"award-info":[{"award-number":["R01\u2010AG23770"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["L30\u2010AG029001"],"award-info":[{"award-number":["L30\u2010AG029001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      We sought to determine if the\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four healthy young adults, i.e., 12 carriers and 12 noncarriers of the\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 allele, were scanned in a subsequent\u2010memory paradigm, using event\u2010related functional magnetic resonance imaging. The neuroanatomic correlates of successful encoding were measured as greater neural activity for subsequently remembered versus forgotten task items, or in short, encoding success activity (ESA). Group differences in ESA within the MTLs, as well as whole\u2010brain functional connectivity with the MTLs, were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the absence of demographic or performance differences,\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 allele carriers exhibited greater bilateral MTL activity relative to noncarriers while accomplishing the same encoding task. Moreover, whereas \u03b54 carriers demonstrated a greater functional connectivity of ESA\u2010related MTL activity with the posterior cingulate and other peri\u2010limbic regions, reductions in overall connectivity were found across the anterior and posterior cortices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results suggest that the\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 allele may influence not only functional activations within the MTL, but functional connectivity of the MTLs to other regions implicated in memory encoding. Enhanced functional connectivity of the MTLs with the posterior cingulate in young adult \u03b54 carriers suggests that\n                      <jats:italic>APOE<\/jats:italic>\n                      may be expressed early in brain regions known to be involved in Alzheimer's disease, long before late\u2010onset dementia is a practical risk or consideration. These functional connectivity differences may also reflect pleiotropic effects of\n                      <jats:italic>APOE<\/jats:italic>\n                      during early development.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2009.07.003","type":"journal-article","created":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T06:15:01Z","timestamp":1252563301000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":190,"title":["Temporal lobe functional activity and connectivity in young adult\n                    <i>APOE<\/i>\n                    \u025b4 carriers"],"prefix":"10.1002","volume":"6","author":[{"given":"Nancy A.","family":"Dennis","sequence":"first","affiliation":[{"name":"Center for Cognitive Neuroscience Duke University Durham NC USA"},{"name":"Department of Psychology Pennsylvania State University University Park PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Browndyke","sequence":"additional","affiliation":[{"name":"Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Durham NC USA"},{"name":"Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences Duke University Medical Center Durham NC USA"},{"name":"Duke Institute for Brain Sciences Duke University Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Stokes","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neuroscience Duke University Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Need","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences and Policy Duke University Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Burke","sequence":"additional","affiliation":[{"name":"Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Durham NC USA"},{"name":"Division of Neurology, Department of Medicine Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Welsh\u2010Bohmer","sequence":"additional","affiliation":[{"name":"Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Durham NC USA"},{"name":"Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences Duke University Medical Center Durham NC USA"},{"name":"Division of Neurology, Department of Medicine Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cabeza","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neuroscience Duke University Durham NC USA"},{"name":"Duke Institute for Brain Sciences 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