{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:48Z","timestamp":1791274488017,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical dementia diagnoses are not always consistent with neuropathological findings. As correct diagnosis is important for treatment and care, new diagnostic possibilities for dementia are in demand. Cerebrospinal fluid biomarkers should ideally be able to identify ongoing processes in the brain, but need to be further compared with neuropathological findings for evaluation of their diagnostic validity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 43 patients with a clinical dementia disorder. All patients were neuropathologically examined at the University Hospital in Lund, Sweden, during the years 2001\u20102008, and all had a lumbar puncture carried out as part of the clinical investigation during the time of cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of eight patients, five with Alzheimer's disease had elevated total tau protein (T\u2010tau) and decreased amyloid beta 1\u201042 protein (A\u03b242), while both values for the other three patients were normal. Slightly elevated T\u2010tau and\/or decreased A\u03b242 were also seen in several patients with other dementia diagnoses such as Lewy body disease, frontotemporal lobar degeneration and vascular dementia. Furthermore, T\u2010tau levels did not differ markedly between patients with morphologically tau\u2010positive and tau\u2010negative frontotemporal lobar degeneration. Also, seven of nine patients with Creutzfeldt\u2010Jacob disease exhibited pronounced elevation in T\u2010tau concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>From this rather limited study, being the first of its kind in Sweden, we may conclude that there is no perfect concordance between cerebrospinal fluid biomarker levels and pathological findings, which should be taken into account in the clinical diagnostic setting.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2009.12.005","type":"journal-article","created":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T05:32:19Z","timestamp":1268803939000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cerebrospinal fluid biomarker results in relation to neuropathological dementia 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