{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:47:25Z","timestamp":1790704045922,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Aging"},{"name":"NIH","award":["5R01AG020094-03"],"award-info":[{"award-number":["5R01AG020094-03"]}]},{"name":"NIH","award":["1P50AG025711-03"],"award-info":[{"award-number":["1P50AG025711-03"]}]},{"name":"Byrd Alzheimer Center"},{"name":"Research Institute grants"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In the diagnosis of Alzheimer's disease (AD), structural magnetic resonance imaging (MRI) scans have been used primarily to exclude non\u2010Alzheimer's causes of dementia. However, the pattern and the extent of medial temporal atrophy on structural MRI scans, which correlate strongly with the pathological severity of AD, can be used to support the diagnosis of a degenerative dementia, especially AD, even in its early predementia stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Elderly subjects (n = 224) were diagnosed with either no cognitive impairment (NCI), amnestic mild cognitive impairment (aMCI), or AD. Hippocampal and hemispheric gray matter volumes were measured on structural MRI scans, and a new visual rating system was used to score the severity of medial temporal atrophy (VRS\u2010MTA) of the hippocampus (HPC), entorhinal cortex, and perirhinal cortex on a coronal image intersecting the mammillary bodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although both VRS\u2010MTA scores and HPC volumes distinguished between subjects with NCI, aMCI, and AD, subjects with aMCI and NCI could be better distinguished using right VRS\u2010MTA scores, in comparison with right HPC volumes. VRS\u2010MTA scores were more highly correlated with episodic memory and Clinical Dementia Rating scores. A combination of left sided VRS\u2010MTA scores and left sided hippocampal volume was the most predictive measure of diagnostic classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VRS\u2010MTA is a clinically convenient method or distinguishing aMCI or AD from NCI. As compared with volumetric measures, it provides better discriminatory power and correlates more strongly with memory and functional scores.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2010.07.002","type":"journal-article","created":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T22:38:42Z","timestamp":1311633522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Volumetric and visual rating of magnetic resonance imaging scans in the diagnosis of amnestic mild cognitive impairment and Alzheimer's disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Qian","family":"Shen","sequence":"first","affiliation":[{"name":"Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center Miami Beach FL USA"},{"name":"Department of Biomedical Engineering University of Miami Coral Gables FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Loewenstein","sequence":"additional","affiliation":[{"name":"Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center Miami Beach FL USA"},{"name":"Department of Psychiatry and Behavioral Sciences Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Potter","sequence":"additional","affiliation":[{"name":"Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center Miami Beach FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Miami Coral Gables FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Appel","sequence":"additional","affiliation":[{"name":"Department of Radiology Mount Sinai Medical Center Miami Beach FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Greig","sequence":"additional","affiliation":[{"name":"Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center Miami Beach FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Radiology Harvard Medical Center Beth Israel Deaconess Hospital Boston MA USA"},{"name":"Johnnie B. 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