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Information on the lifespan work activities was collected. Psychological stress at work was estimated for the longest period of occupation as well as for all occupations by using a validated psychosocial job exposure matrix on two dimensions: job control and job demands. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia and AD in relation to different levels of job stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low level of job control was associated with higher multivariate adjusted risk of dementia (HR = 1.9, 95% CI: 1.2\u20133.0) and AD (HR = 2.2, 95% CI: 1.2\u20133.9). Low level of job demands alone was not significantly associated with increased dementia risk. When the two dimensions were combined into a four\u2010category job strain model, both high job strain (low control\/high demands) and passive strain (both low control and demands) were related to higher risk of dementia and AD as compared with active job strain (both high). Vascular disorders did not mediate the observed associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lifelong work\u2010related psychosocial stress, characterized by low job control and high job strain, was associated with increased risk of dementia and AD in late life, independent of other known risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2011.03.001","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T07:40:03Z","timestamp":1331192403000},"page":"114-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Psychosocial stress at work is associated with increased dementia risk in late life"],"prefix":"10.1002","volume":"8","author":[{"given":"Hui\u2010Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm 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