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At baseline visit, detailed information about medication use was collected and five cognitive domains were assessed. Multivariate linear regression analyses were used to assess cross\u2010sectional associations between medication use and cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 36% of participants reported history of hypertension and 53% reported antihypertensive medication use, with 17% reporting diuretic, 11% ACE\u2010I, and 2% AT2RB use. Potassium\u2010sparing diuretic use (N = 192) was associated with better verbal learning and memory measured by California Verbal Learning Test as compared with no antihypertensive medication users (\u03b2 = 0.068, <jats:italic>P<\/jats:italic> = .01; \u03b2 = 0.094, <jats:italic>P<\/jats:italic> &lt; .001) and other antihypertensive medication users (\u03b2 = 0.080, <jats:italic>P<\/jats:italic>\u00a0= .03; \u03b2 = 0.153, <jats:italic>P<\/jats:italic> &lt; .001). Use of ACE\u2010I or AT2RB was not associated with better cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results warrant further investigation into possible protective effects of potassium\u2010sparing diuretics and the role of potassium in mitigating cognitive decline.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2011.03.010","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T09:51:03Z","timestamp":1333101063000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory study"],"prefix":"10.1002","volume":"8","author":[{"given":"Sevil","family":"Yasar","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine and Gerontology Department of Medicine School of Medicine Johns Hopkins University 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