{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T23:02:25Z","timestamp":1794092545584,"version":"4.8.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.jalz.2011.05.2351","type":"journal-article","created":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T22:37:46Z","timestamp":1311633466000},"page":"367-385","source":"Crossref","is-referenced-by-count":807,"title":["Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer\u2019s Association Research Roundtable Workgroup"],"prefix":"10.1016","volume":"7","author":[{"given":"Reisa A.","family":"Sperling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T.","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Thies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Bednar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald S.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Robert","family":"Brashear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grundman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Siemers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard H.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Schindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jalz.2011.05.2351_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/WAD.0b013e3181c53b00","article-title":"A single ascending dose study of bapineuzumab in patients with Alzheimer disease","volume":"24","author":"Black","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.jalz.2011.05.2351_bib2","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1212\/WNL.0b013e3181c67808","article-title":"A phase 2 multiple ascending dose trial of bapineuzumab in\u00a0mild to moderate Alzheimer disease","volume":"73","author":"Salloway","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib3","series-title":"Risk Factors and clinical course associated with vasogenic edema in a phase II trial of bapineuzumab","year":"2009"},{"key":"10.1016\/j.jalz.2011.05.2351_bib4","doi-asserted-by":"crossref","unstructured":"Sperling R, Bronen R, Greenberg S, Sorensen G, Salloway S, Gass A, et al. Three cases of apparent vasogenic edema (VE) from a Phase 2 clinical trial of the gamma secretase inhibitor BMS-708163 in patients with mild-to-moderate AD. Alzheimer's Association International Conference on Alzheimer's disease. Paris, France; 2011.","DOI":"10.1016\/j.jalz.2011.05.1085"},{"key":"10.1016\/j.jalz.2011.05.2351_bib5","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.1078259","article-title":"Cerebral hemorrhage after passive anti-Abeta immunotherapy","volume":"298","author":"Pfeifer","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jalz.2011.05.2351_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ana.10810","article-title":"Clinical manifestations of cerebral amyloid angiopathy-related inflammation","volume":"55","author":"Eng","year":"2004","journal-title":"Ann Neurol"},{"issue":"Pt 3","key":"10.1016\/j.jalz.2011.05.2351_bib7","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/brain\/awh379","article-title":"Abeta-related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy","volume":"128","author":"Scolding","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.jalz.2011.05.2351_bib8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1212\/01.WNL.0000106951.94624.DF","article-title":"Reversible leukoencephalopathy associated with cerebral amyloid angiopathy","volume":"62","author":"Oh","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib9","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1212\/01.wnl.0000260066.98681.2e","article-title":"Course of cerebral amyloid angiopathy-related inflammation","volume":"68","author":"Kinnecom","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib10","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1212\/01.wnl.0000258985.31455.13","article-title":"A 63-year-old man with headaches and behavioral deterioration","volume":"68","author":"Greenberg","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib11","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1212\/WNL.0b013e31820e773c","article-title":"Anti-Abeta autoantibodies in the CSF of a patient with CAA-related inflammation: a case report","volume":"76","author":"DiFrancesco","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1445-5994.2004.00750.x","article-title":"Reversible posterior leukoencephalopathy syndrome: a misnomer reviewed","volume":"35","author":"Stott","year":"2005","journal-title":"Intern Med J"},{"key":"10.1016\/j.jalz.2011.05.2351_bib13","first-page":"427","article-title":"Reversible posterior leukoencephalopathy syndrome: a retrospective study in King Chulalongkorn Memorial Hospital","volume":"91","author":"Tungkasaereerak","year":"2008","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.jalz.2011.05.2351_bib14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jalz.2011.05.2353","article-title":"Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer's disease study cohorts from phase 3 trials of semagacestat and solanezumab","volume":"7","author":"Carlson","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jalz.2011.05.2351_bib15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ana.410380219","article-title":"Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy","volume":"38","author":"Greenberg","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib16","doi-asserted-by":"crossref","unstructured":"Sperling R, Salloway S, Arrighi M, Morris K, Lu, Liu E, et al. Revised estimates of incidence and risk factors for Amyloid Related Imaging Abnormalities (ARIA) in the Phase 2 studies of bapineuzumab for mild to moderate Alzheimer's disease Alzheimer's Association International Conference on Alzheimer's disease. Paris, France; 2011.","DOI":"10.1016\/j.jalz.2011.09.134"},{"key":"10.1016\/j.jalz.2011.05.2351_bib17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1161\/STROKEAHA.108.526996","article-title":"improving interrater agreement about brain microbleeds: development of the Brain Observer MicroBleed Scale (BOMBS)","volume":"40","author":"Cordonnier","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib18","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1212\/WNL.0b013e3181dad605","article-title":"Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy","volume":"74","author":"Linn","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib19","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000307750.41970.d9","article-title":"Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study","volume":"70","author":"Vernooij","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib20","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/mrm.20198","article-title":"Susceptibility weighted imaging (SWI)","volume":"52","author":"Haacke","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jalz.2011.05.2351_bib21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3233\/JAD-2009-1073","article-title":"Serial susceptibility weighted MRI measures brain iron and microbleeds in dementia","volume":"17","author":"Kirsch","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jalz.2011.05.2351_bib22","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.acra.2008.01.013","article-title":"Detection of asymptomatic cerebral microbleeds: a comparative study at 1.5 and 3.0 T","volume":"15","author":"Stehling","year":"2008","journal-title":"Acad Radiol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib23","first-page":"637","article-title":"Histopathologic analysis of foci of signal loss on gradient-echo T2\u2217-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds","volume":"20","author":"Fazekas","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib24","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/0003-4975(95)00057-R","article-title":"Brain microemboli associated with cardiopulmonary bypass: a histologic and magnetic resonance imaging study","volume":"59","author":"Moody","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jalz.2011.05.2351_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000092958","article-title":"Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than cerebrovascular disease","volume":"22","author":"Nakata-Kudo","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.jalz.2011.05.2351_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jns.2007.03.008","article-title":"Cortico-subcortical distribution of microbleeds is different between hypertension and cerebral amyloid angiopathy","volume":"258","author":"Lee","year":"2007","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jalz.2011.05.2351_bib27","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1212\/WNL.0b013e3181e396ea","article-title":"Incidence of cerebral microbleeds: a longitudinal study in a memory clinic population","volume":"74","author":"Goos","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib28","doi-asserted-by":"crossref","unstructured":"Goos JD, van der Flier WM, Knol DL, Pouwels PJ, Scheltens P, Barkhof F, Wattjes MP. Clinical relevance of improved microbleed detection by susceptibility-weighted magnetic resonance imaging. Stroke 2011 May 12; [Epub ahead of print].","DOI":"10.1161\/STROKEAHA.110.599837"},{"key":"10.1016\/j.jalz.2011.05.2351_bib29","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1212\/01.wnl.0000210535.20297.ae","article-title":"Prevalence and severity of microbleeds in a memory clinic setting","volume":"66","author":"Cordonnier","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib30","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1161\/01.STR.0000131809.35202.1b","article-title":"Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study","volume":"35","author":"Jeerakathil","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib31","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1001\/archneur.65.6.790","article-title":"Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study","volume":"65","author":"Pettersen","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib32","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/jnnp.2007.121913","article-title":"Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location","volume":"79","author":"Sveinbjornsdottir","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Pt 10","key":"10.1016\/j.jalz.2011.05.2351_bib33","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/brain\/awh253","article-title":"Cognitive dysfunction in patients with cerebral microbleeds on T2\u2217-weighted gradient-echo MRI","volume":"127","author":"Werring","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.jalz.2011.05.2351_bib34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/jnnp.2003.015990","article-title":"Comparative analysis of the spatial distribution and severity of cerebral microbleeds and old lacunes","volume":"75","author":"Lee","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jalz.2011.05.2351_bib35","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1161\/STROKEAHA.108.516112","article-title":"Brain microbleeds and global cognitive function in adults without neurological disorder","volume":"39","author":"Yakushiji","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib36","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1253\/circj.CJ-08-0764","article-title":"Asymptomatic cerebral microbleeds seen in healthy subjects have a strong association with asymptomatic lacunar infarction","volume":"73","author":"Igase","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.jalz.2011.05.2351_bib37","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1007\/s00415-003-0245-7","article-title":"Cerebral microbleeds in Alzheimer\u2019s disease","volume":"250","author":"Hanyu","year":"2003","journal-title":"J Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib38","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1212\/WNL.52.5.991","article-title":"MRI evidence of past cerebral microbleeds in a healthy elderly population","volume":"52","author":"Roob","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s002340100649","article-title":"MR detection of microhemorrhages in neurologically healthy adults","volume":"44","author":"Tsushima","year":"2002","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib40","doi-asserted-by":"crossref","unstructured":"Bednar M, Kantarci K, Kupiec J, Burstein A, Landen J, Reyes D, et\u00a0al. The prevalence of brain microhemorrhages and infarcts in a cohort of patients with mild\u2013moderate Alzheimer\u2019s disease. In: International Conference on Alzheimer\u2019s Disease; 2010; Honolulu, Hawaii. P2\u2013372.","DOI":"10.1016\/j.jalz.2010.05.1424"},{"issue":"Suppl 10","key":"10.1016\/j.jalz.2011.05.2351_bib41","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1161\/STROKEAHA.110.595181","article-title":"Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study","volume":"41","author":"Poels","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib42","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/STROKEAHA.109.568469","article-title":"MRI detection of new microbleeds in patients with ischemic stroke: five-year cohort follow-up study","volume":"41","author":"Gregoire","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1474-4422(09)70013-4","article-title":"Cerebral microbleeds: a guide to detection and interpretation","volume":"8","author":"Greenberg","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib44","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1747-4949.2006.00042.x","article-title":"Cerebral microbleeds: old leaks and new haemorrhages","volume":"1","author":"Fiehler","year":"2006","journal-title":"Int J Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib45","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s00415-006-0406-6","article-title":"Initial microbleeds at MR imaging can predict recurrent intracerebral hemorrhage","volume":"254","author":"Jeon","year":"2007","journal-title":"J Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib46","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/01.STR.0000126807.69758.0e","article-title":"Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage","volume":"35","author":"Greenberg","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib47","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1212\/WNL.0b013e3181ae7c5e","article-title":"Superficial siderosis in the general population","volume":"73","author":"Vernooij","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib48","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.STR.32.6.1318","article-title":"A new rating scale for age-related white matter changes applicable to MRI and CT","volume":"32","author":"Wahlund","year":"2001","journal-title":"Stroke"},{"issue":"Suppl 3","key":"10.1016\/j.jalz.2011.05.2351_bib49","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1161\/STROKEAHA.108.537704","article-title":"Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment","volume":"40","author":"Black","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-009-0498-z","article-title":"Microvasculature changes and cerebral amyloid angiopathy in Alzheimer\u2019s disease and their potential impact on therapy","volume":"118","author":"Weller","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1212\/01.wnl.0000223613.57229.24","article-title":"Progression of white matter lesions and hemorrhages in cerebral amyloid angiopathy","volume":"67","author":"Chen","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jalz.2011.05.2351_bib52","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm840","article-title":"Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report","volume":"9","author":"Nicoll","year":"2003","journal-title":"Nat Med"},{"issue":"Pt 12","key":"10.1016\/j.jalz.2011.05.2351_bib53","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/brain\/awn261","article-title":"Consequence of Abeta immunization on the vasculature of human Alzheimer\u2019s disease brain","volume":"131","author":"Boche","year":"2008","journal-title":"Brain"},{"issue":"1048","key":"10.1016\/j.jalz.2011.05.2351_bib54","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jocn.2007.03.009","article-title":"Vasogenic oedema with no mass lesion","volume":"15","author":"Lim","year":"2008","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.jalz.2011.05.2351_bib55","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00005072-199804000-00008","article-title":"Progression of cerebral amyloid angiopathy: accumulation of amyloid-beta40 in affected vessels","volume":"57","author":"Alonzo","year":"1998","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib56","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ana.21164","article-title":"Imaging of amyloid burden and distribution in cerebral amyloid angiopathy","volume":"62","author":"Johnson","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib57","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ana.22099","article-title":"Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy","volume":"68","author":"Dierksen","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib58","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1212\/01.WNL.0000073623.84147.A8","article-title":"Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization","volume":"61","author":"Orgogozo","year":"2003","journal-title":"Neurology"},{"issue":"Suppl 2","key":"10.1016\/j.jalz.2011.05.2351_bib59","doi-asserted-by":"crossref","first-page":"T774","DOI":"10.1016\/j.jalz.2008.05.2416","article-title":"Safety, tolerability and biomarker effects of an A\u03b2 monoclonal antibody administered to patients with Alzheimer\u2019s disease","volume":"4","author":"Siemers","year":"2008","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jalz.2011.05.2351_bib60","unstructured":"XX3. ICAD."},{"key":"10.1016\/j.jalz.2011.05.2351_bib61","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199602223340803","article-title":"A reversible posterior leukoencephalopathy syndrome","volume":"334","author":"Hinchey","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jalz.2011.05.2351_bib62","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3174\/ajnr.A0929","article-title":"Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema","volume":"29","author":"Bartynski","year":"2008","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib63","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1385\/NCC:2:3:303","article-title":"Neuropathological correlates of reversible posterior leukoencephalopathy","volume":"2","author":"Schiff","year":"2005","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.jalz.2011.05.2351_bib64","doi-asserted-by":"crossref","unstructured":"Okeda R, Kawamoto T, Tanaka E, Shimizu H. An autopsy case of drug-induced diffuse cerebral axonopathic leukoencephalopathy: the pathogenesis in relation to reversible posterior leukoencephalopathy syndrome. Neuropathology 27:364\u2013370.","DOI":"10.1111\/j.1440-1789.2007.00771.x"},{"key":"10.1016\/j.jalz.2011.05.2351_bib65","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJMcpc1004364","article-title":"Case records of the Massachusetts General Hospital. Case 22-2010. An 87-year-old woman with dementia and a seizure","volume":"363","author":"Greenberg","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jalz.2011.05.2351_bib66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1750-3639.2004.tb00493.x","article-title":"Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer\u2019s disease","volume":"14","author":"Ferrer","year":"2004","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib67","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1161\/01.STR.30.8.1637","article-title":"Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas","volume":"30","author":"Tanaka","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jalz.2011.05.2351_bib68","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000139661","article-title":"Direct comparison of histology of microbleeds with postmortem MR images: a case report","volume":"26","author":"Tatsumi","year":"2008","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jalz.2011.05.2351_bib69","unstructured":"Schrag M, McAuley G, Pomakian J, Jiffry A, Tung S, Mueller C, et\u00a0al. Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study. Acta Neuropathol (in press)."},{"key":"10.1016\/j.jalz.2011.05.2351_bib70","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/ana.20318","article-title":"AD lesions and infarcts in demented and non-demented Japanese-American men","volume":"57","author":"Petrovitch","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib71","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.21706","article-title":"The neuropathology of probable Alzheimer disease and mild cognitive impairment","volume":"66","author":"Schneider","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib72","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/path.1711480302","article-title":"The validity of negative necropsy reports for metastases in solid organs","volume":"148","author":"Weiss","year":"1986","journal-title":"J Pathol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib73","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.neuroscience.2006.10.020","article-title":"Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid","volume":"144","author":"Wilcock","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.jalz.2011.05.2351_bib74","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1523\/JNEUROSCI.5426-06.2007","article-title":"Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in\u00a0vivo imaging","volume":"27","author":"Prada","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.jalz.2011.05.2351_bib75","doi-asserted-by":"crossref","first-page":"6787","DOI":"10.1523\/JNEUROSCI.2377-07.2008","article-title":"Immunotherapy reduces vascular amyloid-beta in PDAPP mice","volume":"28","author":"Schroeter","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.jalz.2011.05.2351_bib76","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/373523a0","article-title":"Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein","volume":"373","author":"Games","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.jalz.2011.05.2351_bib77","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nm0198-097","article-title":"Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes","volume":"4","author":"Holcomb","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.jalz.2011.05.2351_bib78","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jalz.2011.05.2351_bib79","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in\u00a0vivo: evidence for augmentation of a 42-specific gamma secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jalz.2011.05.2351_bib80","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.jalz.2011.05.2351_bib81","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.jalz.2011.05.2351_bib82","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","article-title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","volume":"94","author":"Sturchler-Pierrat","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jalz.2011.05.2351_bib83","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid beta-protein precursor","volume":"279","author":"Davis","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jalz.2011.05.2351_bib84","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jalz.2011.05.2351_bib85","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1523\/JNEUROSCI.0695-06.2006","article-title":"Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice","volume":"26","author":"Wilcock","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.jalz.2011.05.2351_bib86","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1742-2094-1-24","article-title":"Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage","volume":"1","author":"Wilcock","year":"2004","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jalz.2011.05.2351_bib87","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11481-008-9114-6","article-title":"Deglycosylated anti-Abeta antibody dose-response effects on pathology and memory in APP transgenic mice","volume":"3","author":"Karlnoski","year":"2008","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib88","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1523\/JNEUROSCI.4337-04.2005","article-title":"Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta","volume":"25","author":"Racke","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.jalz.2011.05.2351_bib89","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neurobiolaging.2005.12.003","article-title":"Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage","volume":"28","author":"Burbach","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jalz.2011.05.2351_bib90","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1742-2094-5-42","article-title":"Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice","volume":"5","author":"Petrushina","year":"2008","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jalz.2011.05.2351_bib91","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2174\/187152709787601858","article-title":"Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice","volume":"8","author":"Wilcock","year":"2009","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.jalz.2011.05.2351_bib92","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00429-009-0236-2","article-title":"Immunotherapeutic approaches for Alzheimer\u2019s disease in transgenic mouse models","volume":"214","author":"Wisniewski","year":"2010","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.jalz.2011.05.2351_bib93","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1620\/tjem.220.95","article-title":"Immunization therapy for Alzheimer disease: a comprehensive review of active immunization strategies","volume":"220","author":"Tabira","year":"2010","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.jalz.2011.05.2351_bib94","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1073\/pnas.0813404106","article-title":"Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice","volume":"106","author":"Thakker","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jalz.2011.05.2351_bib95","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-009-0498-z","article-title":"Microvasculature changes and cerebral amyloid angiopathy in Alzheimer\u2019s disease and their potential impact on therapy","volume":"118","author":"Weller","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib96","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","article-title":"Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer\u2019s disease","volume":"18","author":"Weller","year":"2008","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib97","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2990.2007.00926.x","article-title":"Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology","volume":"34","author":"Carare","year":"2008","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib98","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jtbi.2005.07.005","article-title":"Mechanisms to explain the reverse perivascular transport of solutes out of the brain","volume":"238","author":"Schley","year":"2006","journal-title":"J Theor Biol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib99","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.2000.tb06356.x","article-title":"Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer\u2019s disease","volume":"903","author":"Weller","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jalz.2011.05.2351_bib100","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0002-9440(10)65616-7","article-title":"Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer\u2019s disease","volume":"153","author":"Weller","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib101","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1124\/jpet.110.172932","article-title":"Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice","volume":"335","author":"Luo","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jalz.2011.05.2351_bib102","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1750-1326-6-22","article-title":"T cell mediated cerebral hemorrhages and microhemorrhages during passive Abeta immunization in APPPS1 transgenic mice","volume":"6","author":"Meyer-Luehmann","year":"2011","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jalz.2011.05.2351_bib103","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/01.jnen.0000171644.00180.fc","article-title":"Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease","volume":"64","author":"Domnitz","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jalz.2011.05.2351_bib104","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2006.08.017","article-title":"Characterization of amyloid deposition in the APPswe\/PS1dE9 mouse model of Alzheimer disease","volume":"24","author":"Garcia-Alloza","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jalz.2011.05.2351_bib105","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1523\/JNEUROSCI.3854-05.2006","article-title":"Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease","volume":"26","author":"Robbins","year":"2006","journal-title":"J Neurosci"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526011025064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526011025064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:03Z","timestamp":1626912003000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1552526011025064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":105,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S1552526011025064"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2011.05.2351","relation":{},"ISSN":["1552-5260"],"issn-type":[{"value":"1552-5260","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}