{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:40:26Z","timestamp":1788871226928,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009804","name":"Northern California Institute for Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>\n                    Complement receptor 1 gene polymorphism rs3818361 was recently shown to increase the risk of Alzheimer's disease (AD). We performed an independent replication study of this genetic variant in 2470 individuals from Spain. By applying an allelic model, we observed a trend toward an association between this marker and late\u2010onset AD susceptibility in our case\u2013control study (odds ratio = 1.114, 95% confidence interval: 0.958\u20131.296,\n                    <jats:italic>P<\/jats:italic>\n                    = .16). Meta\u2010analysis of available studies (n = 31,771 individuals), including previous studies and public genome\u2010wide association study resources (Alzheimer's Disease Neuroimaging Initiative, Translational Genomics Research Institute, and Multi\u2010site Collaborative Study for Genotype\u2010Phenotype Associations in Alzheimer's Disease), strongly supports the effect of rs3818361 (odds ratio = 1.180, 95% confidence interval: 1.113\u20131.252,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 2.99E\u20108) and suggests the existence of between\u2010study heterogeneity (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .05). We concluded that the complement receptor 1 gene may contribute to AD risk, although its effect size could be smaller than previously estimated.\n                  <\/jats:p>","DOI":"10.1016\/j.jalz.2011.05.2412","type":"journal-article","created":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T22:37:09Z","timestamp":1311633429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Genetic association of complement receptor 1 polymorphism rs3818361 in Alzheimer's disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Carmen","family":"Ant\u00fanez","sequence":"first","affiliation":[{"name":"Dementia Unit, University Hospital Virgen de la Arrixaca Murcia Spain"},{"name":"AlzheimUr Foundation Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Boada","sequence":"additional","affiliation":[{"name":"Memory Clinic of Fundaci\u00d3 ACE, Institut Catal\u00e0 de Neurci\u00e8ncies Aplicades Barcelona Spain"},{"name":"Institut de Recerca, Universitat Aut\u00f2noma de Barcelona (VHIR\u2010UAB), Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"L\u00d3pez\u2010Arrieta","sequence":"additional","affiliation":[{"name":"Memory Unit, University Hospital La Paz\u2010Cantoblanco Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concha","family":"Moreno\u2010Rey","sequence":"additional","affiliation":[{"name":"Department of Structural Genomics Neocodex Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Memory Clinic of Fundaci\u00d3 ACE, Institut Catal\u00e0 de Neurci\u00e8ncies Aplicades Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Dementia Unit, University Hospital Virgen de la Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gay\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Structural Genomics Neocodex Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gonz\u00e1lez\u2010P\u00c9rez","sequence":"additional","affiliation":[{"name":"Department of Structural Genomics Neocodex Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Real","sequence":"additional","affiliation":[{"name":"Department of Structural Genomics Neocodex Sevilla 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.439"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.440"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.229102"},{"key":"e_1_2_4_5_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3233\/JAD-2010-1357","article-title":"CALHM1 P86L polymorphism is associated with late\u2010onset Alzheimer's disease in a recessive model","volume":"20","author":"Boada M","year":"2010","journal-title":"J Alzheimers 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