{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T14:17:07Z","timestamp":1781446627623,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T00:00:00Z","timestamp":1344211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01 AG029336"],"award-info":[{"award-number":["K01 AG029336"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A highly polymorphic T homopolymer was recently found to be associated with late\u2010onset Alzheimer's disease risk and age of onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the effects of the polymorphic polyT tract (rs10524523, referred as \u2018523\u2019) on cognitive performance in cognitively healthy elderly individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred eighty\u2010one participants were recruited from local independent\u2010living retirement communities. Informed consent was obtained, and participants completed demographic questionnaires, a conventional paper\u2010and\u2010pencil neuropsychological battery, and the computerized Cambridge Neuropsychological Test Automated Battery (CANTAB). Saliva samples were collected for determination of the <jats:italic>TOMM40<\/jats:italic> \u2018523\u2019 (S, L, VL) and the apolipoprotein E (<jats:italic>APOE<\/jats:italic>) (\u03b52, 3, 4) genotypes. From the initial sample of 181 individuals, 127 were eligible for the association analysis. Participants were divided into three groups based on \u2018523\u2019 genotypes (S\/S, S\/L\u2010S\/VL, and L\/L\u2010L\/VL\u2010VL\/VL). Generalized linear models were used to evaluate the association between the \u2018523\u2019 genotypes and neuropsychological test performance. Analyses were adjusted for age, sex, education, depression, and <jats:italic>APOE<\/jats:italic> \u03b54 status. A planned subanalysis was undertaken to evaluate the association between \u2018523\u2019 genotypes and test performance in a sample restricted to <jats:italic>APOE<\/jats:italic> \u03b53 homozygotes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The S homozygotes performed better, although not significantly, than the S\/L\u2010S\/VL and the VL\/L\u2010L\/VL\u2010VL\/VL genotype groups on measures associated with memory (CANTAB Paired Associates Learning, Verbal Recognition Memory free recall) and executive function (CANTAB measures of Intra\u2010Extra Dimensional Set Shift). Follow\u2010up analysis of <jats:italic>APOE<\/jats:italic> \u03b53 homozygotes only showed that the S\/S group performed significantly better than the S\/VL group on measures of episodic memory (CANTAB Paired Associates Learning and Verbal Recognition Memory free recall), attention (CANTAB Rapid Visual Information Processing latency), and executive function (Digit Symbol Substitution). The S\/S group performed marginally better than the VL\/VL group on Intra\u2010Extra Dimensional Set Shift. None of the associations remained significant after applying a Bonferroni correction for multiple testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results suggest important <jats:italic>APOE<\/jats:italic>\u2010independent associations between the <jats:italic>TOMM40<\/jats:italic> \u2018523\u2019 polymorphism and specific cognitive domains of memory and executive control that are preferentially affected in early\u2010stage Alzheimer's disease.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2011.10.005","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T11:01:29Z","timestamp":1343991689000},"page":"381-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["A homopolymer polymorphism in the <i>TOMM40<\/i> gene contributes to cognitive performance in aging"],"prefix":"10.1002","volume":"8","author":[{"given":"Kathleen 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