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Progression in CDR\u2010SB over time as a function of baseline global CDR was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A longitudinal increase (<jats:italic>P<\/jats:italic> &lt; .0001) in CDR\u2010SB was observed. The annual rate of change in CDR\u2010SB scores was 1.43 (standard error [SE] = 0.05) in the CDR 0.5 sample and 1.91 (SE = 0.07) in the CDR 1 sample. For participants followed from the beginning of the CDR stage, time to progression to a higher global CDR was longer for individuals who were CDR 0.5 (3.75 years; 95% confidence interval [CI]: 3.18\u20134.33) than those who were CDR 1 at baseline (2.98 years; 95% CI: 2.75\u20133.22). In the total CDR 0.5 sample, the significant predictors of progression to the next global CDR stage (<jats:italic>P<\/jats:italic> &lt; .01) were age at first sAD diagnosis and apolipoprotein E4 genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study findings are relevant to sAD clinical trial design and accurate, reliable ascertainment of the effect of disease\u2010modifying treatments.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2012.01.005","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T12:45:33Z","timestamp":1343825133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Progression of Alzheimer's disease as measured by Clinical Dementia Rating Sum of Boxes scores"],"prefix":"10.1002","volume":"9","author":[{"given":"Monique M.","family":"Williams","sequence":"first","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer's 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