{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:47:40Z","timestamp":1792259260089,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000544"],"award-info":[{"award-number":["81000544"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171209"],"award-info":[{"award-number":["81171209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Five genomewide association studies (GWAS) in white populations have recently identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (<jats:italic>CLU<\/jats:italic>, <jats:italic>CR1<\/jats:italic>, <jats:italic>PICALM, BIN1<\/jats:italic>, <jats:italic>ABCA7<\/jats:italic>, <jats:italic>MS4A<\/jats:italic> gene cluster, <jats:italic>CD2AP<\/jats:italic>, <jats:italic>CD33,<\/jats:italic> and <jats:italic>EPHA1<\/jats:italic>). These studies have been conducted almost exclusively in white populations and it is unclear whether these observations generalize to populations with different ethnicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 1224 unrelated northern Han Chinese subjects comprising 612 patients with a clinical diagnosis of late\u2010onset AD (LOAD) according to the criteria of the National Institute of Neurological and Communicative Diseases and Stroke\/Alzheimer's Disease and Related Disorders Association and 612 healthy age\u2010 and sex\u2010matched control subjects. Because of our previous study investigating <jats:italic>CLU, CR1,<\/jats:italic> and <jats:italic>PICALM<\/jats:italic> in the Han population, we limited the current analysis to <jats:italic>BIN1<\/jats:italic>, <jats:italic>ABCA7<\/jats:italic>, <jats:italic>MS4A<\/jats:italic> gene cluster, <jats:italic>CD2AP<\/jats:italic>, <jats:italic>CD33<\/jats:italic>, and <jats:italic>EPHA1<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a multivariate analysis, associations of <jats:italic>MS4A6A<\/jats:italic> (rs610932; odds ratio = 0.632, Bonferroni corrected <jats:italic>P<\/jats:italic> = .019) and <jats:italic>CD33<\/jats:italic> (rs3865444; odds ratio = 1.492, Bonferroni corrected <jats:italic>P<\/jats:italic> = .017) with LOAD were replicated successfully. When these data were stratified by apolipoprotein E (<jats:italic>APOE<\/jats:italic>) \u03b54 status, both rs610932 and rs610932 were evident only among subjects without the <jats:italic>APOE<\/jats:italic> \u03b54 allele. For <jats:italic>BIN1<\/jats:italic>, assuming a dominant model of inheritance, a positive association for rs7561528 in <jats:italic>APOE<\/jats:italic> \u03b54 carriers was observed. This association, however, did not remain significant after Bonferroni correction. As for <jats:italic>ABCA7<\/jats:italic>, <jats:italic>CD2AP,<\/jats:italic> and <jats:italic>EPHA1<\/jats:italic> single nucleotide polymorphisms from recent GWAS, despite the similar directional effects, no significant differences in genotype and estimated allele frequency distribution between patients and control subjects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides the first independent evidence that <jats:italic>MS4A<\/jats:italic> and <jats:italic>CD33<\/jats:italic> loci are associated with the risk of LOAD in northern Han Chinese population. Genotypes at the two loci confer risk predominantly in <jats:italic>APOE<\/jats:italic> \u03b54\u2010negative subjects.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2012.08.007","type":"journal-article","created":{"date-parts":[[2012,12,8]],"date-time":"2012-12-08T18:01:45Z","timestamp":1354989705000},"page":"546-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["Association of GWAS\u2010linked loci with late\u2010onset Alzheimer's disease in\u00a0a northern Han Chinese population"],"prefix":"10.1002","volume":"9","author":[{"given":"Lan","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, School of Medicine Qingdao University PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Tai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, School of Medicine Qingdao 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