{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:31:06Z","timestamp":1790976666692,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Alzheimer's disease (AD) is an epidemic facing the entire world. Increased knowledge gained during the past 25 years indicates that AD falls along a clinical and neuropathological spectrum represented as a continuum that extends from preclinical disease in which there are no symptoms, through early symptomatic phases, and finally to AD dementia. The Alzheimer's research community recognizes that imaging, body fluids, and cognitive biomarkers contribute to enhanced diagnostic confidence for AD. There has also been emerging consensus regarding the use of AD biomarkers in clinical trials. The use of biomarkers in clinical trials and practice is hampered by the lack of standardization. In response to the emerging need for standardization, an international meeting of AD researchers was held in Melbourne, Australia, in March 2012 to bring together key researchers, clinicians, industry, and regulatory stakeholders with the aim of generating consensus on standardization and validation of cognitive, imaging, and fluid biomarkers, as well as lifestyle parameters used in research centers worldwide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2012.10.006","type":"journal-article","created":{"date-parts":[[2012,12,23]],"date-time":"2012-12-23T05:30:43Z","timestamp":1356240643000},"page":"160-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Research and standardization in Alzheimer's trials: Reaching international consensus"],"prefix":"10.1002","volume":"9","author":[{"given":"Maria C.","family":"Carrillo","sequence":"first","affiliation":[{"name":"Alzheimer's Association Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Austin Health Heidelberg Victoria 3084 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Szoeke","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"The Mental Health Research Institute The University of Melbourne Parkville Victoria 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ames","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute Parkville Victoria 3052 Australia"},{"name":"Academic Unit for Psychiatry of Old Age, Department of Psychiatry The University of Melbourne Parkville Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"O'Meara","sequence":"additional","affiliation":[{"name":"CSIRO Preventative Health Flagship Materials Science and Engineering Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Lance","family":"Macaulay","sequence":"additional","affiliation":[{"name":"CSIRO Preventative Health Flagship Materials Science and Engineering Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Milner","sequence":"additional","affiliation":[{"name":"Neurosciences Victoria Carlton South Victoria 3053 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Academic Unit for Psychiatry of Old Age, Department of Psychiatry The University of Melbourne Parkville Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"The Mental Health Research Institute The University of Melbourne Parkville Victoria 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Rainey\u2010Smith","sequence":"additional","affiliation":[{"name":"Edith Cowan University Joondalup Western Australia 6027 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[{"name":"Edith Cowan University Joondalup Western Australia 6027 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Bain","sequence":"additional","affiliation":[{"name":"Independent Science Writer Elverson PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Head","sequence":"additional","affiliation":[{"name":"CSIRO Preventative Health Flagship Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_2_10_3_1","article-title":"Introduction to revised criteria for the diagnosis of Alzheimer's disease: National Institute on Aging and the Alzheimer's Association workgroup","author":"Jack CR","year":"2011","journal-title":"Alzheimers Dement"},{"key":"e_1_2_10_4_1","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging and the Alzheimer's Association workgroup","author":"McKhann GM","year":"2011","journal-title":"Alzheimers Dement"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_10_6_1","article-title":"Revised criteria for mild cognitive impairment may compromise the diagnosis of Alzheimer Disease dementia","author":"Morris JC","year":"2012","journal-title":"Arch Neurol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt59"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-0059"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22608"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000115751"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.04.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.215"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq321"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"e_1_2_10_16_1","unstructured":"European Medicines Agency.Qualification opinion of low hippocampal volume (atrophy) by MRI for use in regulatory clinical trials in pre\u2010dementia stage of Alzheimer's disease. Available at: <http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Regulatory_and_procedural_guideline\/2011\/10\/WC500116264.pdf11 >. Accessed April\u00a02012."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.06.007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.04.007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.78.1_MeetingAbstracts.S04.003","article-title":"Delphi consensus on landmarks for the manual segmentation of the hippocampus on MRI: preliminary results from the EADC\u2010ADNI Harmonization Protocol Working Group (S04.003)","volume":"78","author":"Boccardi M","year":"2012","journal-title":"Neurology"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1208061"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.2008"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70077-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22068"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06812.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.045385"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.094946"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.198.3.8628880"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006213"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.024"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3987-10.2010"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.4"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.155"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.08.003"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903044982"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031084"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2221"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.081679"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","DOI":"10.4061\/2010\/610613","article-title":"Lessons from multicenter studies on CSF biomarkers for Alzheimer's disease","author":"Mattsson N","year":"2010","journal-title":"Int J Alzheimers Dis"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3233\/JAD-2011-110212","article-title":"Preanalytical sample handling and sample stability testing for the neurochemical dementia diagnostics","volume":"25","author":"Zimmermann R","year":"2011","journal-title":"J\u00a0Alzheimers Dis"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2243"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt30"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl279"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028527"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.3405"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003124"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.12.1454"},{"key":"e_1_2_10_49_1","article-title":"Physical activity and amyloid\u2010beta plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing","author":"Brown BM","year":"2012","journal-title":"Mol Psychiatry"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1146"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20854"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.007369"},{"key":"e_1_2_10_53_1","unstructured":"Global Alzheimer's Association Interactive Network www.gaain.org. Accessed April\u00a02012."},{"key":"e_1_2_10_54_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2012.05.2115","article-title":"Common Alzheimer's research ontology: National Institute on Aging and Alzheimer's Association collaborative project","volume":"8","author":"Refolo LM","year":"2012","journal-title":"Alzheimers Dement"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526012024983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526012024983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2012.10.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2012.10.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2012.10.006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2012.10.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:57:02Z","timestamp":1759946222000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2012.10.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,26]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1016\/j.jalz.2012.10.006"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2012.10.006","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,26]]},"assertion":[{"value":"2012-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}