{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T17:05:07Z","timestamp":1765731907601,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"5S","license":[{"start":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to estimate differences in rates of functional decline in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia (VaD) and whether differences vary by age or sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data came from 32 U.S. Alzheimer's Disease Centers. The cohort of participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a05848) were \u226560\u00a0years of age and had clinical dementia with a primary etiologic diagnosis of probable AD, DLB, or probable VaD; a Clinical Dementia Rating\u2010Sum of Boxes score\u00a0&lt;16; and a duration of symptoms \u226410 years. Dementia diagnoses were assigned using standard criteria. Annual mean rate of change of the Functional Activities Questionnaire (FAQ) score was modeled using multiple linear regression with generalized estimating equations adjusted for demographics, comorbidities, years since onset, and cognitive status (mean follow\u2010up\u00a0=\u00a02.0 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FAQ declined more slowly over time in those with VaD compared with AD (difference in mean annual rate of change: \u22120.91; 95% confidence interval [CI]: \u22121.68, \u22120.14). VaD participants also declined at a slower rate than DLB participants, but this difference was not statistically significant (\u22120.61; 95% CI: \u22121.45, 0.24). There was no significant difference between DLB and AD. Within each group, rate of decline was more rapid for the youngest participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this sample, findings suggested that VaD patients declined in their functional abilities at a slower rate compared with AD patients and that there were no significant differences in rate of functional decline between patients with DLB compared with those with either AD or VaD. These results may provide guidance to clinicians about average expected rates of functional decline in three common dementia types.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2012.10.010","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T12:36:09Z","timestamp":1367498169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Differences in rate of functional decline across three dementia types"],"prefix":"10.1002","volume":"9","author":[{"given":"Dawn P.","family":"Gill","sequence":"first","affiliation":[{"name":"Aging, Rehabilitation &amp; Geriatric Care Research Centre Lawson Health Research Institute London Ontario Canada"},{"name":"National Alzheimer's Coordinating Center University of Washington Seattle WA USA"},{"name":"Department of Epidemiology University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Group Health Research Institute Seattle WA USA"},{"name":"Department of Biostatistics University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Koepsell","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center University of Washington Seattle WA USA"},{"name":"Department of Epidemiology University of Washington Seattle WA USA"},{"name":"Department of Health Services University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Borrie","sequence":"additional","affiliation":[{"name":"Aging, Rehabilitation &amp; 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