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The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>T2*\u2010weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (<jats:italic>P<\/jats:italic> &lt; .005), and this was associated with individual Mini\u2010Mental State Examination scores (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.54, <jats:italic>P<\/jats:italic> &lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased cortical phase shift in AD patients demonstrated on 7\u2010tesla T2*\u2010weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2013.02.002","type":"journal-article","created":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T00:03:15Z","timestamp":1369440195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker"],"prefix":"10.1002","volume":"10","author":[{"given":"Sanneke","family":"van Rooden","sequence":"first","affiliation":[{"name":"C.J. Gorter Center for High\u2010Field MRI Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten J.","family":"Versluis","sequence":"additional","affiliation":[{"name":"C.J. Gorter Center for High\u2010Field MRI Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Milles","sequence":"additional","affiliation":[{"name":"Division of Image Processing Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea B.","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatrics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ania M.","family":"Oleksik","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatrics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Webb","sequence":"additional","affiliation":[{"name":"C.J. 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