{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:44:17Z","timestamp":1793295857191,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long\u2010run longitudinal study and a meta\u2010analysis of published studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants (n = 1671) were monitored for up to 22 years from a baseline personality assessment. The meta\u2010analysis pooled results from up to five prospective studies (n = 5054).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individuals with scores in the top quartile of neuroticism (hazard ratio = 3.1; 95% confidence interval = 1.6\u20136.0) or the lowest quartile of conscientiousness (hazard ratio\u00a0=\u00a03.3; 95% confidence interval = 1.4\u20137.4) had a threefold increased risk of incident AD. Among the components of these traits, self\u2010discipline and depression had the strongest associations with incident AD. The meta\u2010analysis confirmed the associations of neuroticism (\n                      <jats:italic>P<\/jats:italic>\n                      = 2 \u00d7 10\n                      <jats:sup>\u22129<\/jats:sup>\n                      ) and conscientiousness (\n                      <jats:italic>P<\/jats:italic>\n                      = 2 \u00d7 10\n                      <jats:sup>\u22126<\/jats:sup>\n                      ), along with weaker effects for openness and agreeableness (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current study and meta\u2010analysis indicate that personality traits are associated with increased risk of AD, with effect sizes similar to those of well\u2010established clinical and lifestyle risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2013.03.002","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T17:38:20Z","timestamp":1369157900000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":253,"title":["Personality and risk of Alzheimer's disease: New data and meta\u2010analysis"],"prefix":"10.1002","volume":"10","author":[{"given":"Antonio","family":"Terracciano","sequence":"first","affiliation":[{"name":"National Institute on Aging National Institutes of Health Baltimore MD USA"},{"name":"Florida State University College of Medicine Tallahassee FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina R.","family":"Sutin","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health Baltimore MD USA"},{"name":"Florida State University College of Medicine Tallahassee FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"An","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B.","family":"Zonderman","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Resnick","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.02.001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"e_1_2_6_4_2","unstructured":"Alzheimer's Disease International.World Alzheimer report 2011: the benefits of early diagnosis and intervention.\u00a02011. 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