{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:33:40Z","timestamp":1792784020012,"version":"4.5.0"},"reference-count":133,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Katharina-Hardt-Foundation"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The development of validated, qualified, and standardized biomarkers for Alzheimer's disease (AD) that allow for an early presymptomatic diagnosis and discrimination (classification) from other types of dementia and neurodegenerative diseases is warranted to accelerate the successful development of novel disease\u2010modifying therapies. Here, we focus on the value of the 42\u2010residue\u2010long amyloid \u03b2 isoform (A\u03b21\u201042) peptide in the cerebrospinal fluid as the core, feasible neurobiochemical marker for the amyloidogenic mechanisms in early\u2010onset familial and late\u2010onset sporadic AD. We discuss the role and use of A\u03b21\u201042 in combination with evolving neuroimaging biomarkers in AD detection and diagnosis. Multimodal neuroimaging techniques, directly providing structural\u2010functional\u2010metabolic aspects of brain pathophysiology, are supportive to predict and monitor the progression of the disease. Advances in multimodal neuroimaging provide new insights into brain organization and enable the detection of specific proteins and\/or protein aggregates associated with AD. The combination of biomarkers from different methodologies is believed to be of incrementally added risk\u2010value to accurately identify asymptomatic and prodromal individuals who will likely progress to dementia and represent rational biomarker candidates for preventive and symptomatic pharmacological intervention trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2013.04.506","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T09:45:20Z","timestamp":1373535920000},"page":"381-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["CSF A\u03b21\u201042 combined with neuroimaging biomarkers in the early detection, diagnosis and prediction of Alzheimer's disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Simone","family":"Lista","sequence":"first","affiliation":[{"name":"Department of Psychiatry Goethe\u2010University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco G.","family":"Garaci","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology, and Radiotherapy University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"IRCCS San Raffaele Pisana Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ewers","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California at San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Teipel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Rostock Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"DZNE German Center for Neurodegenerative Diseases Rostock Germany"},{"name":"Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry The Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"DZNE German Center for Neurodegenerative Diseases Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Hampel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Goethe\u2010University Frankfurt am Main Germany"},{"name":"University College London Institute of Neurology Queen Square London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.11.008"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4521-10.2010"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.4"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3115"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1740774512437252"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.002"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0808-0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-19"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00350-5"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.04.381"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl280"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70223-4"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.05.2116"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.04.003"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/JAD-2006-9S346","article-title":"Diagnosis of Alzheimer's disease: two\u2010decades of progress","volume":"9","author":"Khachaturian Z.S.","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986708783955572"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.087"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900345106"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2620"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0419"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1977"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.088"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2494"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04426.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006221","article-title":"Fluid biomarkers in Alzheimer disease","volume":"2","author":"Blennow K.","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000311703"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720509788486509"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.09.024"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2009.08.002"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.213"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.08.006"},{"key":"e_1_2_7_40_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/jnnp.2010.217778","article-title":"Do CSF biomarkers help clinicians predict the progression of mild cognitive impairment to dementia?","volume":"10","author":"Mitchell A.J.","year":"2010","journal-title":"Pract Neurol"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1159\/000335729"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70228-4"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1159\/000115975"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200800006"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-012-0801-3"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000046581.81650.D0"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20730"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.03.029"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.596"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0543-z"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10661"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1159\/000048642"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10321"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512460603"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-9-63"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20524"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701585104"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.11.006"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2168"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20508"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1159\/000100926"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1064"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70355-6"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000156914.16988.56"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001473"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-89"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00818.x"},{"key":"e_1_2_7_69_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-61779-418-6_8","article-title":"Protein profiling of cerebrospinal fluid","volume":"818","author":"Simonsen A.H.","year":"2012","journal-title":"Methods Mol Biol"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1048"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01818.x"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.051201"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr050475v"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.09.044"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr0703627"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200900166"},{"key":"e_1_2_7_77_2","doi-asserted-by":"publisher","DOI":"10.1159\/000203774"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.06.002"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.1159\/000334537"},{"key":"e_1_2_7_80_2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3233\/JAD-2010-100573","article-title":"Acute effect on the A\u03b2 isoform pattern in CSF in response to \u03b3\u2010secretase modulator and inhibitor treatment in dogs","volume":"21","author":"Portelius E.","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt30"},{"key":"e_1_2_7_82_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JAD-2012-120508","article-title":"Amyloid\u2010\u03b2(1\u201015\/16) as a marker for \u03b3\u2010secretase inhibition in Alzheimer's disease","volume":"31","author":"Portelius E.","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_7_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2009.06.003"},{"key":"e_1_2_7_84_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.09.65"},{"key":"e_1_2_7_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.008"},{"key":"e_1_2_7_86_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-121471"},{"key":"e_1_2_7_87_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000228591","article-title":"Future screening for incipient Alzheimer's disease\u2014the influence of prevalence on test performance","volume":"62","author":"Mattsson N.","year":"2009","journal-title":"Eur Neurol"},{"key":"e_1_2_7_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.05.005"},{"key":"e_1_2_7_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.036"},{"key":"e_1_2_7_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.06.006"},{"key":"e_1_2_7_91_2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/mrm.22689","article-title":"Anisotropic anomalous diffusion assessed in the human brain by scalar invariant indices","volume":"65","author":"De\u2010Santis S.","year":"2011","journal-title":"Magn Reson Med"},{"key":"e_1_2_7_92_2","unstructured":"HLu JHJensen CHu MFFalangola ARamani SFerris et\u00a0al.Alterations in cerebral microstructural integrity in normal aging and in Alzheimer's disease: a multi\u2010contrast diffusion MRI study.Presented at the 14th Scientific Meeting of the ISMRM Seattle WA 2006. p.\u00a0723."},{"key":"e_1_2_7_93_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12110433"},{"key":"e_1_2_7_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr271"},{"key":"e_1_2_7_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.07.002"},{"key":"e_1_2_7_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"e_1_2_7_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.01.027"},{"key":"e_1_2_7_98_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.064360"},{"key":"e_1_2_7_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.10.019"},{"key":"e_1_2_7_100_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021896"},{"key":"e_1_2_7_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.05.023"},{"key":"e_1_2_7_102_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181af79fb"},{"key":"e_1_2_7_103_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111703"},{"key":"e_1_2_7_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03539.x"},{"key":"e_1_2_7_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.12.017"},{"key":"e_1_2_7_106_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1397"},{"key":"e_1_2_7_107_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bc010c"},{"key":"e_1_2_7_108_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e8e8b8"},{"key":"e_1_2_7_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.05.006"},{"key":"e_1_2_7_110_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3233\/JAD-2009-0968","article-title":"Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease","volume":"16","author":"Brys M.","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_7_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.020"},{"key":"e_1_2_7_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.12.002"},{"key":"e_1_2_7_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.06.009"},{"key":"e_1_2_7_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.022"},{"key":"e_1_2_7_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.04.056"},{"key":"e_1_2_7_116_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0048-3"},{"key":"e_1_2_7_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.11.001"},{"key":"e_1_2_7_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.011"},{"key":"e_1_2_7_119_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120832"},{"key":"e_1_2_7_120_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000286944.22262.ff"},{"key":"e_1_2_7_121_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-112118"},{"key":"e_1_2_7_122_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826e2696"},{"key":"e_1_2_7_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.09.172"},{"key":"e_1_2_7_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.005"},{"key":"e_1_2_7_125_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3811"},{"key":"e_1_2_7_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.11.009"},{"key":"e_1_2_7_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.07.004"},{"key":"e_1_2_7_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.07.008"},{"key":"e_1_2_7_129_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.pneurobio.2011.09.011","article-title":"The role of genetics for biomarker development in neurodegeneration","volume":"95","author":"Bertram L.","year":"2011","journal-title":"Prog Neurobiol"},{"key":"e_1_2_7_130_2","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrneurol.2012.202","article-title":"Alzheimer disease: from inherited to sporadic AD\u2010crossing the biomarker bridge","volume":"8","author":"Hampel H.","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"e_1_2_7_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70139-5"},{"key":"e_1_2_7_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.008"},{"key":"e_1_2_7_133_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt138"},{"key":"e_1_2_7_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.11.005"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526013006572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526013006572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2013.04.506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2013.04.506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2013.04.506","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2013.04.506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:55:41Z","timestamp":1759856141000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2013.04.506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,15]]},"references-count":133,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1016\/j.jalz.2013.04.506"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2013.04.506","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,15]]},"assertion":[{"value":"2013-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}