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Alleles of this locus are classified as S, short; L, long; and VL, very long based on the number of T residues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated differences in\n                      <jats:italic>APOE<\/jats:italic>\n                      messenger RNA (mRNA) and\n                      <jats:italic>TOMM40<\/jats:italic>\n                      mRNA levels as a function of the 523 genotype in two brain regions from\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b53\/\u03b53 white autopsy\u2010confirmed LOAD cases and normal controls. We further investigated the effect of the 523 locus in its native genomic context using a luciferase expression system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The expression of both genes was significantly increased with disease. Mean expression of\n                      <jats:italic>APOE<\/jats:italic>\n                      and\n                      <jats:italic>TOMM40<\/jats:italic>\n                      mRNA levels were higher in VL homozygotes compared with S homozygotes in the temporal and occipital cortexes from normal and LOAD cases. Results of a luciferase reporter system were consistent with the human brain mRNA analysis; the 523 VL poly\u2010T resulted in significantly higher expression than the S poly\u2010T. Although the effect of poly\u2010T length on reporter expression was the same in HepG2 hepatoma and SH\u2010SY5Y neuroblastoma cells, the magnitude of the effect was greater in the neuroblastoma than in the hepatoma cells, which implies tissue\u2010specific modulation of the 523 poly\u2010T.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results suggest that the 523 locus may contribute to LOAD susceptibility by modulating the expression of\n                      <jats:italic>TOMM40<\/jats:italic>\n                      and\/or\n                      <jats:italic>APOE<\/jats:italic>\n                      transcription.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2013.08.280","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T10:31:46Z","timestamp":1389781906000},"page":"541-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["The\n                    <i>cis<\/i>\n                    \u2010regulatory effect of an Alzheimer's disease\u2010associated poly\u2010T locus on expression of\n                    <i>TOMM40<\/i>\n                    and apolipoprotein E genes"],"prefix":"10.1002","volume":"10","author":[{"given":"Colton","family":"Linnertz","sequence":"first","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"},{"name":"Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Crenshaw","sequence":"additional","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"},{"name":"Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"},{"name":"Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawara","family":"Allen","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences &amp; Policy, Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Saith","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences &amp; Policy, Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirta","family":"Mihovilovic","sequence":"additional","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Burke","sequence":"additional","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"},{"name":"Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Welsh\u2010Bohmer","sequence":"additional","affiliation":[{"name":"Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen D.","family":"Roses","sequence":"additional","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"},{"name":"Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Medical Center Durham NC USA"},{"name":"Zinfandel Pharmaceuticals Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornit","family":"Chiba\u2010Falek","sequence":"additional","affiliation":[{"name":"Division of Neurology at the Department of Medicine Duke University Medical Center Durham NC USA"},{"name":"Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Medical Center Durham NC USA"},{"name":"Institute for Genome Sciences &amp; 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