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However, whether imatinib has this effect in humans is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma levels of A\u03b242 were analyzed in sequential samples from CML patients treated with imatinib (<jats:italic>n<\/jats:italic>\u00a0=\u00a051). The effect of imatinib on A\u03b2 production was also investigated in human embryonic kidney 293 (HEK293) cells overexpressing the amyloid precursor protein (APP) with the Swedish mutation, in mouse primary cortical neurons and in human Down syndrome embryonic stem\u2010cell\u2010derived cortical neurons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve months of imatinib treatment did not lower plasma A\u03b242 levels in CML patients, and imatinib treatment did not lead to less A\u03b242 production in any of the in\u00a0vitro models whereas \u03b2\u2010 and \u03b3\u2010secretase inhibitors did.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data question the previously described role of imatinib in inhibiting amyloidogenic APP processing and as a drug candidate for AD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2013.08.283","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T04:45:29Z","timestamp":1386650729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Imatinib treatment and A\u03b242 in humans"],"prefix":"10.1002","volume":"10","author":[{"given":"Bob","family":"Olsson","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry The Sahlgrenska Academy University of Gothenburg M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Legros","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique H\u00f4pital de l'Archet Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guilhot","sequence":"additional","affiliation":[{"name":"INSERM CIC 0802 CHU de Poitiers Poitiers 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