{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T04:05:22Z","timestamp":1794197122533,"version":"4.8.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U44NS065518"],"award-info":[{"award-number":["U44NS065518"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01\u2010NS50895"],"award-info":[{"award-number":["R01\u2010NS50895"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01\u2010AG20241"],"award-info":[{"award-number":["R01\u2010AG20241"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["IIRG\u201012\u2010239626"],"award-info":[{"award-number":["IIRG\u201012\u2010239626"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["NIRG\u201013\u2010281227"],"award-info":[{"award-number":["NIRG\u201013\u2010281227"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG000096"],"award-info":[{"award-number":["AG000096"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As a prelude to clinical trials we have characterized B\u2010 and T\u2010cell immune responses in macaques to AD vaccine candidates: AV\u20101955 and its slightly modified version, AV\u20101959 (with 3 additional promiscuous Th epitopes).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>T\u2010 and B\u2010cell epitope mapping was performed using the ELISPOT assay and competition ELISA, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AV\u20101955 and AV\u20101959 did not stimulate potentially harmful autoreactive T cells, but instead activated a broad but individualized repertoire of Th cells specific to the MultiTEP platform in macaques. Although both vaccines induced robust anti\u2010A\u03b2 antibody responses without producing antibodies specific to Th epitopes of MultiTEP platforms, analyses of cellular immune responses in macaques demonstrated that the addition of Th epitopes in the case of AV\u20101959 created a more potent, superior vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AV\u20101959 is a promising vaccine candidate capable of producing therapeutically potent anti\u2010amyloid antibody in a broader population of vaccinated subjects with high MHC class II gene polymorphisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2013.12.003","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T15:15:23Z","timestamp":1392909323000},"page":"271-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The MultiTEP platform\u2013based Alzheimer's disease epitope vaccine activates a broad repertoire of T helper cells in nonhuman primates"],"prefix":"10.1002","volume":"10","author":[{"given":"Hayk","family":"Davtyan","sequence":"first","affiliation":[{"name":"Department of Molecular Immunology Institute for Molecular Medicine Huntington Beach CA USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahit","family":"Ghochikyan","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology Institute for Molecular Medicine Huntington Beach CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Petrushina","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders University of California Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armine","family":"Hovakimyan","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology Institute for Molecular Medicine Huntington Beach CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpine","family":"Davtyan","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology Institute for Molecular Medicine Huntington Beach CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Cribbs","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders University of California Irvine Irvine CA USA"},{"name":"Department of Neurology University of California Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Agadjanyan","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology Institute for Molecular Medicine Huntington Beach CA USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1234"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04134.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.07.012"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000073623.84147.A8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn938"},{"key":"e_1_2_6_10_2","first-page":"628070","article-title":"Targeting beta amyloid: a clinical review of immunotherapeutic approaches in Alzheimer's disease","volume":"2012","author":"Lobello K.","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000159740.16984.3C"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61075-2"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000240466.10758.ce"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060269"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.00927.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151261398"},{"key":"e_1_2_6_17_2","unstructured":"Eli Lilly and Company announces top\u2010line results on Solanezumab Phase 3 clinical trials in patients with Alzheimer's disease 2012. 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