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Many of its pathologic features and cognitive deficits may be due in part to brain insulin resistance recently demonstrated in the insulin receptor\u2192insulin receptor substrate\u20101 (IRS\u20101) signaling pathway. The proximal cause of such resistance in AD dementia and amnestic mild cognitive impairment (aMCI) appears to be serine inhibition of IRS\u20101, a phenomenon likely due to microglial release of inflammatory cytokines triggered by oligomeric A\u03b2. Studies on animal models of AD and on human brain tissue from MCI cases at high risk of AD dementia have shown that brain insulin resistance and many other pathologic features and symptoms of AD may be greatly reduced or even reversed by treatment with FDA\u2010approved glucagon\u2010like peptide\u20101 (GLP\u20101) analogs such as liraglutide (Victoza). 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