{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:24:20Z","timestamp":1790231060024,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Cerebral aggregation of amyloid\u2010\u03b2 (A\u03b2) is thought to play a major role in the etiology of Alzheimer's disease. Environmental influences, including chronic bacterial or viral infections, are thought to alter the permeability of the blood\u2010brain barrier (BBB) and thereby facilitate cerebral colonization by opportunistic pathogens. This may eventually trigger A\u03b2 overproduction and aggregation. Host biomolecules that target and combat these pathogens, for instance, antimicrobial peptides (AMPs) such as A\u03b2 itself, are an interesting option for the detection and diagnostic follow\u2010up of such cerebral infections. As part of the innate immune system, AMPs are defensive peptides that efficiently penetrate infected cells and tissues beyond many endothelial barriers, most linings, including the BBB, and overall specifically target pathogens. Based on existing literature, we postulate a role for labeled AMPs as a marker to target pathogens that play a role in the aggregation of amyloid in the brain.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2013.12.020","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T18:46:06Z","timestamp":1395254766000},"page":"51-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Potential role of antimicrobial peptides in the early onset of Alzheimer's disease"],"prefix":"10.1002","volume":"11","author":[{"given":"Mick M.","family":"Welling","sequence":"first","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J.A.","family":"Nabuurs","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"van der Weerd","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Human Genetics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,17]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2011.02.005"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.215"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.08.007"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt24"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107920.110"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.5.530"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000308937.30473.d1"},{"key":"e_1_2_11_10_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1079\/9781845936570.0181","volume-title":"Antimicrobial peptides. Discovery, design and novel therapeutic strategies","author":"White JH","year":"2010"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000178444.33972.e0"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-151"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1007320"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00007-10"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.12.021"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/501862"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-7-16"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxs007"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.04.006"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(03)00127-1"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2009.09.002"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00624-10"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00473-11"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050036"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7799(02)00032-X"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2008.08.005"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874196700902020163"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450024605445"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-007-0064-5"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.278.6.C1063"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-010-0089-7"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009505"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502031200"},{"key":"e_1_2_11_34_2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1021\/mp200419b","article-title":"Antimicrobial properties of amyloid peptides","volume":"9","author":"Kagan BL","year":"2011","journal-title":"Mol Pharmaceut"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505249200"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1866"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-199208"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-0102ufm"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0502-484"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00196-07"},{"key":"e_1_2_11_41_2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/MNM.0b013e32833a3d7f","article-title":"Clinical trial of specific imaging of infections","volume":"31","author":"Murphy CA","year":"2010","journal-title":"Nucl Med Commun"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.12.042"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01202-08"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152709787601867"},{"key":"e_1_2_11_46_2","first-page":"79","article-title":"Brain lactoferrin: an endogenous peptide or merely an intruder","volume":"2","author":"Marrif HI","year":"2009","journal-title":"Am J Sci Res"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2449"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2002.tb11470.x"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10519"},{"key":"e_1_2_11_50_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1212\/WNL.0b013e3181e7b6a4","article-title":"Alzheimer disease and HIV","volume":"75","author":"Brew BJ","year":"2010","journal-title":"Neurology"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.10.010"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-51"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.08.043"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181f73bc2"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000203644.68059.5f"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.3.805"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067484"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526014000119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526014000119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2013.12.020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2013.12.020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2013.12.020","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2013.12.020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T20:14:33Z","timestamp":1759868073000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2013.12.020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,17]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1016\/j.jalz.2013.12.020"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2013.12.020","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,17]]},"assertion":[{"value":"2014-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}