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Eighty\u2010four AD patients underwent an assessment of vascular risk (blood pressure, cholesterol, smoking, cardiovascular disease, diabetes, atrial fibrillation, transient ischemic attack [TIA], or stroke) and later underwent brain autopsy. Given our aim to examine mild cerebrovascular changes (CVCs), individuals were excluded if autopsy revealed large stroke. The most common forms of CVC were circle of Willis atherosclerosis followed by arteriosclerosis, lacunes, and microinfarcts. Excluding the history of TIA\/clinical stroke, individual vascular risk factors were not associated with CVC. However, the presence of multiple vascular risk factors was associated with CVC. Furthermore, the presence of CVC was associated with lower Braak and Braak stage. These findings highlight the importance of aggregate risk in the vascular contribution to dementia. Interventions designed to maintain cerebrovascular health may represent important opportunities for preventing or delaying dementia, even when AD is the dominant pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2013.12.025","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T22:31:35Z","timestamp":1404858695000},"page":"394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy\u2010confirmed Alzheimer's disease"],"prefix":"10.1002","volume":"11","author":[{"given":"Katherine J.","family":"Bangen","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California  San Diego, La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Nation","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Delano\u2010Wood","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego, La Jolla CA USA"},{"name":"Veterans Affairs San Diego Healthcare System  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gali H.","family":"Weissberger","sequence":"additional","affiliation":[{"name":"San Diego State University\/University of California, San Diego Joint Doctoral Program in Clinical Psychology  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California  San Diego, La Jolla CA USA"},{"name":"Department of Pathology University of California  San Diego, La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Galasko","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego CA USA"},{"name":"Department of Neurosciences University of California  San Diego, La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California  San Diego, La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Bondi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego, La Jolla CA USA"},{"name":"Veterans Affairs San Diego Healthcare System  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172914.08967.dc"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000149519.47454.F2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(05)80010-4"},{"key":"e_1_2_7_5_1","volume-title":"Epidemiology: beyond the basics","author":"Szklo M","year":"2000"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? 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