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How to use, interpret, and disclose biomarker results drives the need for standardization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Previous Alzheimer's Biomarkers Standardization Initiative meetings discussed preanalytical issues affecting A\u03b2\n                      <jats:sub>1\u201042<\/jats:sub>\n                      and tau in CSF. This second round of consensus meetings focused on issues related to clinical use of AD CSF biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Consensus was reached that lumbar puncture for AD CSF biomarker analysis be considered as a routine clinical test in patients with early\u2010onset dementia, at the prodromal stage or with atypical AD. Moreover, consensus was reached on which biomarkers to use, how results should be interpreted, and potential confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Changes in A\u03b2\n                      <jats:sub>1\u201042<\/jats:sub>\n                      , T\u2010tau, and P\u2010tau\n                      <jats:sub>181P<\/jats:sub>\n                      allow diagnosis of AD in its prodromal stage. Conversely, having all three biomarkers in the normal range rules out AD. Intermediate conditions require further patient follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2014.03.003","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T12:45:53Z","timestamp":1408538753000},"page":"808-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":177,"title":["The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative"],"prefix":"10.1002","volume":"10","author":[{"given":"Jos\u00e9 Luis","family":"Molinuevo","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Clinic i Universitari, IDIBAPS and Barcelona Beta Research Centre Pasqual Maragall Foundation Barcelona 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