{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:01:14Z","timestamp":1775080874202,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T00:00:00Z","timestamp":1403913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 DC010367"],"award-info":[{"award-number":["R01 DC010367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Apolipoprotein E \u03b54 (<jats:italic>APOE<\/jats:italic> \u03b54) is a risk factor for \u03b2\u2010amyloid deposition in Alzheimer's disease dementia. Its influence on \u03b2\u2010amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred thirty subjects with PPA or progressive speech apraxia underwent <jats:italic>APOE<\/jats:italic> genotyping and Pittsburgh compound B (PiB) PET scanning. The relationship between <jats:italic>APOE<\/jats:italic> \u03b54 and PiB status, as well as severity and regional distribution of PiB, was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five subjects had an <jats:italic>APOE<\/jats:italic> \u03b54 allele and 60 subjects were PiB\u2010positive. The odds ratio for a subject with <jats:italic>APOE<\/jats:italic> \u03b54 being PiB\u2010positive compared with a subject without <jats:italic>APOE<\/jats:italic> \u03b54 being PiB\u2010positive was 10.2 (95% confidence interval, 4.4\u201325.5; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). The <jats:italic>APOE<\/jats:italic> \u03b54 allele did not influence regional PiB distribution or severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>APOE<\/jats:italic> \u03b54 increases the risk of \u03b2\u2010amyloid deposition in PPA and progressive speech apraxia but does not influence regional \u03b2\u2010amyloid distribution or severity.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2014.03.004","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T09:46:00Z","timestamp":1403948760000},"page":"630-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>APOE<\/i> \u03b54 influences \u03b2\u2010amyloid deposition in primary progressive aphasia and speech apraxia"],"prefix":"10.1002","volume":"10","author":[{"given":"Keith A.","family":"Josephs","sequence":"first","affiliation":[{"name":"Division of Behavioral Neurology Department 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