{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:47:07Z","timestamp":1780696027594,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical criteria are important for improving diagnostic accuracy and ensuring comparability of patient cohorts in research studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to assess the National Institute on Aging and Alzheimer's Association (NIA\u2010AA) criteria for Alzheimer's disease (AD) dementia in AD and frontotemporal lobar degeneration (FTLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred twelve consecutive patients with pathologically confirmed AD or FTLD who were clinically assessed in a specialist cognitive unit were identified. Fifty\u2010five patients were excluded predominantly because of insufficient clinical information. Anonymized clinical data were rated against the NIA\u2010AA criteria by raters who were blinded to clinical and pathologic diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The NIA\u2010AA AD dementia criteria had a sensitivity of 65.6% for probable and 79.5% for possible AD and a specificity of 95.2% and 94.0% for probable and possible, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with FTLD and predominantly early\u2010onset AD, the NIA\u2010AA AD dementia criteria have high specificity but lower sensitivity. The high specificity is due to the broad exclusion criteria.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2014.04.516","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T22:32:12Z","timestamp":1404858732000},"page":"207-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Do NIA\u2010AA criteria distinguish Alzheimer's disease from frontotemporal dementia?"],"prefix":"10.1002","volume":"11","author":[{"given":"Jennifer M.","family":"Harris","sequence":"first","affiliation":[{"name":"Manchester Academic Health Sciences Centre Cerebral Function Unit Greater Manchester Neuroscience Centre Salford Royal NHS Foundation Trust Salford UK"},{"name":"Institute of Brain Behaviour and Mental Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer 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