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Appropriate correction isolates microstructural effects in MCI that might be precursors of Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight participants (18 MCI, 15 AD, and 15 healthy controls) had magnetic resonance imaging scans and clinical evaluations at baseline and follow\u2010up after 36\u00a0months. Ten MCI subjects were diagnosed with AD at follow\u2010up and eight remained MCI. Free\u2010water (FW) corrected measures on the white matter skeleton were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FW corrected radial diffusivity, but not uncorrected radial diffusivity, was increased across the brain of the converted group compared with the nonconverted group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The extent of increases was similar to that found comparing AD with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Partial volume elimination reveals microstructural alterations preceding dementia. These alterations may prove to be an effective and feasible early biomarker of AD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2014.04.518","type":"journal-article","created":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T09:00:13Z","timestamp":1405328413000},"page":"485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Widespread white matter degeneration preceding the onset of dementia"],"prefix":"10.1002","volume":"11","author":[{"given":"Klaus H.","family":"Maier-Hein","sequence":"first","affiliation":[{"name":"Department of Radiology Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"},{"name":"Junior Group Medical Image Computing German Cancer Research Center  Heidelberg Germany"},{"name":"Junior Group Quantitative Image-based Disease Characterization German Cancer Research Center  Heidelberg 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