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Here, we examined whether individuals with apolipoprotein E gene (\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54) have increased parietal WMH volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants were from the Washington Heights\u2010Inwood Columbia Aging Project (WHICAP; n\u00a0=\u00a0694, 47 with dementia) in northern Manhattan and the Etude Sant\u00e9 Psychologique Pr\u00e9valence Risques et Traitement study (ESPRIT; n\u00a0=\u00a0539, 8 with dementia) in Montpellier. The association between regional WMH and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 was examined separately in each group and then in a combined analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In WHICAP, \u03b54 carriers had higher WMH volume particularly in parietal and occipital lobes. In ESPRIT, \u03b54 carriers had elevated WMH particularly in parietal and temporal lobes. In the combined analysis, \u03b54 carriers had higher WMH in parietal and occipital lobes. Increased WMH volume was associated with increased frequency of dementia irrespective of\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 status; those with the \u03b54 were more likely to have dementia if they also had increased parietal WMH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 is associated with increased parietal lobe WMH.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2014.07.155","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T03:26:07Z","timestamp":1412825167000},"page":"619-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["<i>APOE<\/i>\n                    \u03b54 and risk for Alzheimer's disease: Do regionally distributed white matter hyperintensities play a role?"],"prefix":"10.1002","volume":"10","author":[{"given":"Adam M.","family":"Brickman","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University New York NY USA"},{"name":"G.H. 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