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Recently, the largest genome\u2010wide association study in AAs to date confirmed that six of the Alzheimer's disease (AD)\u2010related genetic variants originally discovered in EA cohorts are also risk variants in AA; however, the risk attributable to many of the loci (e.g., APOE, ABCA7) differed substantially from previous studies in EA. There likely are risk variants of higher frequency in AAs that have not been discovered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a comprehensive analysis of genetically determined local and global ancestry in AAs with regard to LOAD status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, LOAD cases showed higher levels of African ancestry, both globally and at several LOAD relevant loci, which explained risk for AD beyond global differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Exploratory post hoc analyses highlight regions with greatest differences in ancestry as potential candidate regions for future genetic analyses.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.02.012","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T18:20:06Z","timestamp":1434478806000},"page":"233-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Global and local ancestry in African\u2010Americans: Implications for Alzheimer's disease risk"],"prefix":"10.1002","volume":"12","author":[{"given":"Timothy J.","family":"Hohman","sequence":"first","affiliation":[{"name":"Center for Human Genetics and Research Vanderbilt University School of Medicine  Nashville TN USA"},{"name":"Department of Molecular Physiology &amp; Biophysics Vanderbilt University School of Medicine  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica N.","family":"Cooke\u2010Bailey","sequence":"additional","affiliation":[{"name":"Center for Human Genetics and Research Vanderbilt University School of Medicine  Nashville TN USA"},{"name":"Department of Molecular Physiology &amp; Biophysics Vanderbilt University School of Medicine  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Reitz","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons Columbia University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyungah","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Boston University School of Medicine  Boston MA USA"},{"name":"Department of Medicine (Biomedical Genetics) Boston University School of Medicine  Boston MA USA"},{"name":"Department of Biostatistics Boston University School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Naj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Beecham","sequence":"additional","affiliation":[{"name":"Dr. John T. 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