{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:41:33Z","timestamp":1761489693051,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T00:00:00Z","timestamp":1434153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009240","name":"Sveriges Kommuner och Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>New research guidelines for the diagnosis of Alzheimer's disease (AD) include biomarker evidence of amyloid\u2010\u03b2 (A\u03b2) and tau pathology. The aim of this study was to investigate what proportion of AD patients diagnosed in clinical routine in Sweden that had an AD\u2010indicative cerebrospinal fluid (CSF) biomarker profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By cross\u2010referencing a laboratory database with the Swedish Dementia Registry (SveDem), 2357 patients with data on CSF A\u03b2 and tau biomarkers and a clinical diagnosis of AD with dementia were acquired.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 77.2% had pathologic A\u03b2<jats:sub>42<\/jats:sub> and total tau or phosphorylated tau in CSF. These results were stable across age groups. Female sex and low mini\u2010mental state examination score increased the likelihood of pathologic biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>About a quarter of clinically diagnosed AD patients did not have an AD\u2010indicative CSF biomarker profile. This discrepancy may partly reflect incorrect (false positive) clinical diagnosis or a lack in sensitivity of the biomarker assays.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.04.007","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T09:38:19Z","timestamp":1434274699000},"page":"1470-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Benchmarking biomarker\u2010based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem"],"prefix":"10.1002","volume":"11","author":[{"given":"Christoffer","family":"Ros\u00e9n","sequence":"first","affiliation":[{"name":"Clinical Neurochemistry Laboratory Department of Neurochemistry Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahman","family":"Farahmand","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research, Division of Clinical Geriatrics Department of Neurobiology Care Sciences, and Society (NVS), Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Geriatric Medicine Karolinska University Hospital  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Skillb\u00e4ck","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Department of Neurochemistry Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"N\u00e4gga","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Mattsson","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Department of Neurochemistry Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Kilander","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences\/Geriatrics Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Religa","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Karolinska University Hospital  Huddinge Sweden"},{"name":"Center for Alzheimer Research, Division for Neurogeriatrics Department of Neurobiology Care Sciences, and Society (NVS), Karolinska Institutet  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Wimo","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research, Division for Neurogeriatrics Department of Neurobiology Care Sciences, and Society (NVS), Karolinska Institutet  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Department of Neurochemistry Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Karolinska University Hospital  Huddinge Sweden"},{"name":"Center for Alzheimer Research, Division for Neurogeriatrics Department of Neurobiology Care Sciences, and Society (NVS), Karolinska Institutet  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Department of Neurochemistry Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Department of Molecular Neuroscience UCL Institute of Neurology  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Eriksdotter","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research, Division of Clinical Geriatrics Department of Neurobiology Care Sciences, and Society (NVS), Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Geriatric Medicine Karolinska University Hospital  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,13]]},"reference":[{"volume-title":"The ICD\u201010 classification of mental and behavioural disorders: Diagnostic criteria for research","year":"1993","author":"World Health Organization","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-20"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.05.1753"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"volume-title":"About SveDem, Swedish Dementia Registry","year":"2014","author":"SveDem","key":"e_1_2_8_12_1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/302553"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3925"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337038"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3233\/JAD-2012-120019","article-title":"Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment","volume":"30","author":"Mattsson N","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1151-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815140"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01036-3"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.6.673"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1358"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70355-6"},{"volume-title":"Model selection and multimodel inference a practical information\u2010theoretic approach","year":"2002","author":"Burnham KP","key":"e_1_2_8_23_1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.9.1143"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31824b211b"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.02.016"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3233\/JAD-131085","article-title":"Validation of the AD\u2010CSF\u2010index in autopsy\u2010confirmed Alzheimer's disease patients and healthy controls","volume":"41","author":"Struyfs H","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.596"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.10.017"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.81"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000366194","article-title":"The use of MRI, CT and lumbar puncture in dementia diagnostics: Data from the SveDem Registry","volume":"39","author":"Falahati F","year":"2014","journal-title":"Dement Geriatr Cogn Disord"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2243"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.12.46"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.003"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321121"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.02.007"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109998"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bd8271"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3233\/JAD-2011-101911","article-title":"Longitudinal changes of CSF biomarkers in Alzheimer's disease","volume":"25","author":"Seppala TT","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355556"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2353"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053587"},{"key":"e_1_2_8_45_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000362164","article-title":"Increased levels of chitotriosidase and YKL\u201040 in cerebrospinal fluid from patients with Alzheimer's disease","volume":"4","author":"Rosen C","year":"2014","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1064"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526015001855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526015001855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2015.04.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2015.04.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2015.04.007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2015.04.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T18:59:59Z","timestamp":1759863599000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2015.04.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,13]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1016\/j.jalz.2015.04.007"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2015.04.007","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"subject":[],"published":{"date-parts":[[2015,6,13]]},"assertion":[{"value":"2015-06-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}