{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:09:23Z","timestamp":1793459363086,"version":"4.5.0"},"reference-count":175,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007333","name":"Alzheimer's Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201012\u20102\u20100012"],"award-info":[{"award-number":["W81XWH\u201012\u20102\u20100012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology. Here, we provide an update on sample collection, scientific progress and opportunities, conceptual issues, and future plans.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Lymphoblastoid cell lines and DNA and RNA samples from blood have been collected and banked, and data and biosamples have been widely disseminated. To date,\n APOE<\/jats:italic>\n genotyping, genome\u2010wide association study (GWAS), and whole exome and whole genome sequencing data have been obtained and disseminated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n ADNI genetic data have been downloaded thousands of times, and >300 publications have resulted, including reports of large\u2010scale GWAS by consortia to which ADNI contributed. Many of the first applications of quantitative endophenotype association studies used ADNI data, including some of the earliest GWAS and pathway\u2010based studies of biospecimen and imaging biomarkers, as well as memory and other clinical\/cognitive variables. Other contributions include some of the first whole exome and whole genome sequencing data sets and reports in healthy controls, mild cognitive impairment, and AD.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Numerous genetic susceptibility and protective markers for AD and disease biomarkers have been identified and replicated using ADNI data and have heavily implicated immune, mitochondrial, cell cycle\/fate, and other biological processes. Early sequencing studies suggest that rare and structural variants are likely to account for significant additional phenotypic variation. Longitudinal analyses of transcriptomic, proteomic, metabolomic, and epigenomic changes will also further elucidate dynamic processes underlying preclinical and prodromal stages of disease. Integration of this unique collection of multiomics data within a systems biology framework will help to separate truly informative markers of early disease mechanisms and potential novel therapeutic targets from the vast background of less relevant biological processes. Fortunately, a broad swath of the scientific community has accepted this grand challenge.<\/jats:p>\n <\/jats:sec>","DOI":"10.1016\/j.jalz.2015.05.009","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:32:19Z","timestamp":1437093139000},"page":"792-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":299,"title":["Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans"],"prefix":"10.1002","volume":"11","author":[{"given":"Andrew J.","family":"Saykin","sequence":"first","affiliation":[{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN USA"},{"name":"Indiana Alzheimer Disease Center Indiana University School of Medicine Indianapolis IN USA"},{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN USA"},{"name":"Indiana Alzheimer Disease Center Indiana University School of Medicine Indianapolis IN USA"},{"name":"Center for Computational Biology and Bioinformatics Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Yao","sequence":"additional","affiliation":[{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN USA"},{"name":"School of Informatics and Computing Indiana University, Purdue University \u2013 Indianapolis Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN USA"},{"name":"Indiana Alzheimer Disease Center Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsik","family":"Nho","sequence":"additional","affiliation":[{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN USA"},{"name":"Indiana Alzheimer Disease Center Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Risacher","sequence":"additional","affiliation":[{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN USA"},{"name":"Indiana Alzheimer Disease Center Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Ramanan","sequence":"additional","affiliation":[{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN USA"},{"name":"Indiana Alzheimer Disease Center Indiana University School of Medicine Indianapolis IN USA"},{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M.","family":"Foroud","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer Disease Center Indiana University School of Medicine Indianapolis IN USA"},{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley M.","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Sarwar","sequence":"additional","affiliation":[{"name":"Eisai Ltd. Hatfield Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne M.","family":"Munsie","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Hu","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Wallingford CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly D.","family":"Soares","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Wallingford CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Potkin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human behavior University of California \u2013 Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keck School of Medicine of USC University of Southern California Marina del Rey CA USA"},{"name":"Imaging Genetics Center, Keck School of Medicine of USC University of Southern California Marina del Rey CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.K.","family":"Kauwe","sequence":"additional","affiliation":[{"name":"Department of Biology Brigham Young University Provo UT USA"},{"name":"Department of Neuroscience Brigham Young University Provo UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Kaddurah\u2010Daouk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Duke University Durham NC USA"},{"name":"Duke Institute for Brain Sciences Duke University Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Green","sequence":"additional","affiliation":[{"name":"Partners Center for Personalized Genetic Medicine Boston MA USA"},{"name":"Division of Genetics Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging, Institute for Neuroimaging and Neuroinformatics, Keck School of Medicine of USC University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California\u2010San Francisco San Francisco CA USA"},{"name":"Department of Medicine University of California\u2010San Francisco San Francisco CA USA"},{"name":"Department of Psychiatry University of California\u2010San Francisco San Francisco CA USA"},{"name":"Center for Imaging of Neurodegenerative Diseases San Francisco VA Medical Center San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"RisacherSL KimS NhoK ForoudTM ShenL PetersenRC et al.APOE effect on Alzheimer's biomarkers in older adults with significant memory concern.Alzheimers Dement2015https:\/\/doi.org\/10.1016\/j.jalz.2015.03.003. [Epub ahead of print]","DOI":"10.1016\/j.jalz.2015.03.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1769"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt59"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2802"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/13546800903059829"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006501"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-013-9262-z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.7.1046"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43176-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10060"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.157901"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.88"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/mp.2013.81","article-title":"Identification of functional variants from whole\u2010exome sequencing, combined with neuroimaging genetics","volume":"18","author":"Nho K","year":"2013","journal-title":"Mol Psychiatry"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.24"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300337"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2248"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.026"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.174"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.217"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3314"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021643"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.06.001"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-28"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070269"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.86"},{"issue":"7","key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/mp.2014.81","article-title":"HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study","volume":"20","author":"Leduc V","year":"2014","journal-title":"Mol Psychiatry"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2014.01.141","article-title":"Genetic variation of oxidative phosphorylation genes in stroke and Alzheimer's disease","volume":"35","author":"Biffi A","year":"2014","journal-title":"Neurobiol Aging"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107983"},{"key":"e_1_2_7_34_1","unstructured":"DesikanRS SchorkAJ WangY WitoelarA SharmaM McEvoyLK et al.Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.Mol Psychiatry2015 Feb 17"},{"key":"e_1_2_7_35_1","first-page":"145","article-title":"Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders","volume":"2","author":"Ramanan VK","year":"2013","journal-title":"Am J Neurodegener Dis"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24349"},{"key":"e_1_2_7_37_1","unstructured":"NhoK SaykinAJ.Reply to letter to the editor.Ann Neurol2015 Apr 20"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13163"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.12.022"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00183"},{"key":"e_1_2_7_41_1","doi-asserted-by":"crossref","unstructured":"RoussotteFF GutmanBA HibarDP MadsenSK NarrKL ThompsonPM et al.Carriers of a common variant in the dopamine transporter gene have greater dementia risk cognitive decline and faster ventricular expansion.Alzheimers Dement: the journal of the Alzheimer's Association2014 Dec 10","DOI":"10.1016\/j.jalz.2014.10.011"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5236-13.2014"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22247"},{"key":"e_1_2_7_44_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnagi.2013.00093","article-title":"A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly","volume":"5","author":"Roussotte FF","year":"2013","journal-title":"Front Aging Neurosci"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.06.007"},{"key":"e_1_2_7_46_1","first-page":"1565","article-title":"TREM2 and neurodegenerative disease","volume":"369","author":"Rajagopalan P","year":"2013","journal-title":"N Engl J Med"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3233\/JAD-130989","article-title":"Genetic interactions within inositol\u2010related pathways are associated with longitudinal changes in ventricle size","volume":"38","author":"Koran ME","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.07.020"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.12.012"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216206110"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.05.024"},{"key":"e_1_2_7_52_1","doi-asserted-by":"crossref","unstructured":"JahanshadN BhattP HibarDP VillalonJE NirTM TogaAW et\u00a0al.Bivariate genome\u2010wide association study of genetically correlated neuroimaging phenotypes from DTI and MRI through a seemingly unrelated regression model.MICCAI MBIA Workshop 2013.Nagoya Japan2013.","DOI":"10.1007\/978-3-319-02126-3_19"},{"key":"e_1_2_7_53_1","doi-asserted-by":"crossref","unstructured":"JahanshadN KochunovP GlahnD BlangeroJ NicholsTE McMahonKL et\u00a0al.Power estimates for voxel\u2010based genetic association studies using diffusion imaging.MICCAI MBIA Workshop 2013.Nagoya Japan2013. p.12.","DOI":"10.1007\/978-3-319-02475-2_21"},{"key":"e_1_2_7_54_1","doi-asserted-by":"crossref","unstructured":"WarstadtNM JahanshadN DennisEL KohannimO McMahonKL De ZubicarayGI et\u00a0al.Identifying candidate gene effects by restricting search space in a multivariate genetic analysis of white matter microstructure.IEEE International Symposium on Biomedical Imaging.Beijing China2014.","DOI":"10.1109\/ISBI.2014.6867881"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-011-9136-1"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3435"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.19"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.08.015"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.007"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.048"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00011"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu465"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.08.032"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067163"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.065"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120010"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.11.009"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.026"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.185"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004758"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu372"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4829"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1763"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.033"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.803"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000431"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824365ab"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182553c48"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.008"},{"issue":"5","key":"e_1_2_7_81_1","first-page":"429","article-title":"FASTKD2 is associated with memory and hippocampal structure in older adults","volume":"16","author":"Ramanan VK","year":"2014","journal-title":"Mol Psychiatry"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.8"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14101"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105829109"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.02.032"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003685"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9196-x"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-013-9259-7"},{"key":"e_1_2_7_89_1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3233\/JAD-148009","article-title":"Comprehensive gene\u2010 and pathway\u2010based analysis of depressive symptoms in older adults","volume":"45","author":"Nho K","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.03.004"},{"key":"e_1_2_7_91_1","first-page":"388","article-title":"The genetics of cognitive ability and cognitive ageing in healthy older people","volume":"15","author":"Harris SE","year":"2011","journal-title":"Trends Cogn Sci"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.07.005"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235488"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809437"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.137"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047739"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00035-7"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076001"},{"key":"e_1_2_7_99_1","unstructured":"LimYY VillemagneVL LawsSM PietrzakRH SnyderPJ AmesD et al.APOE and BDNF polymorphisms moderate amyloid beta\u2010related cognitive decline in preclinical Alzheimer's disease.Mol Psychiatry2014 Oct 7"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.07.014"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32101"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30658"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129837"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3868"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.06.018"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00260"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70259-4"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.27.11.499"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.016"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2011.09.002"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2355"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10112"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2918"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.803"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.801"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.09.023"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv092"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322563111"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12415"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.030"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.07.002"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn250"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.092"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1491"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312889"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr348"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-012-0920-x"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.8934"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.7215"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4309"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4051"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7325"},{"key":"e_1_2_7_134_1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jalz.2014.05.1757","article-title":"Convergent genetic and expression data implicate immunity in Alzheimer's disease","volume":"11","author":"International Genomics of Alzheimer's Disease Consortium","year":"2015","journal-title":"Alzheimers Dement"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3102"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1689808"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr394"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10821"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0121"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.02.004"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13800"},{"key":"e_1_2_7_143_1","article-title":"Managing incidental findings in human subjects research: analysis and recommendations","volume":"36","author":"Wolf SM","year":"2008","journal-title":"J Law Med Ethics"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu217"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.10.001"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/15877332"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823d7687"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/73283917"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.04.009"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.133"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.23"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.24.4.448.1039"},{"key":"e_1_2_7_153_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1176\/appi.ajp.2013.12121590","article-title":"Knowledge of APOE genotype affects subjective and objective memory performance in healthy older adults","volume":"171","author":"Lineweaver T","year":"2013","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_154_1","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1371\/journal.pmed.0050091","article-title":"Communicating the results of clinical research to participants: attitudes, practices, and future directions","volume":"5","author":"Shalowitz DI","year":"2008","journal-title":"PLoS Med"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.1704"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt206"},{"key":"e_1_2_7_157_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3233\/JAD-2012-121216","article-title":"Dementia specialists and early adoption of amyloid imaging","volume":"33","author":"Klein EP","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_7_158_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2967\/jnumed.113.120618","article-title":"Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association","volume":"54","author":"Johnson K","year":"2013","journal-title":"J Nucl Med"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.06.001"},{"key":"e_1_2_7_160_1","unstructured":"National Coverage Analysis.Proposed decision memo for beta amyloid positron emission tomography in dementia and neurodegenerative disease (CAG\u201000431N). Centers for Medicare and Medicaid Services (CMS). Available at:http:\/\/www.cms.gov\/medicare\u2010coverage\u2010database\/details\/nca\u2010proposed\u2010decision\u2010memo.aspx?NCAId=265. Accessed June 25 2015."},{"key":"e_1_2_7_161_1","unstructured":"RogersMB.Coverage denial for amyloid scans riles Alzheimer's community.AlzForum2013 Available at:http:\/\/www.alzforum.org\/news\/conference\u2010coverage\/coverage\u2010denial\u2010amyloid\u2010scans\u2010riles\u2010alzheimers\u2010community. Accessed June 25 2015"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a55f4a"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.10"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31393"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.958827"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1312543"},{"key":"e_1_2_7_167_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.14601"},{"key":"e_1_2_7_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.73"},{"key":"e_1_2_7_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.151"},{"key":"e_1_2_7_170_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.41703"},{"key":"e_1_2_7_171_1","unstructured":"WolfSM BranumR KoenigBA PetersenGM BerrySA BeskowLM et al.Returning a research participant's genomic results to relatives: analysis and recommendations.J Law Med Ethics2015 In press"},{"key":"e_1_2_7_172_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809578"},{"key":"e_1_2_7_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2011.01739.x"},{"key":"e_1_2_7_174_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-092010-110722"},{"key":"e_1_2_7_175_1","unstructured":"GreenRC ChristensenKD CupplesLA RelkinNR WhitehousePJ RoyalCD et al.A randomized noninferiority trial of condensed protocols for genetic risk disclosure of Alzheimer's disease.Alzheimers Dement2014 Dec 9"},{"key":"e_1_2_7_176_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1229566","article-title":"Identifying personal genomes by surname inference","volume":"339","author":"Gymrek M","year":"2012","journal-title":"Science"}],"container-title":["Alzheimer's & Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526015001776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526015001776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2015.05.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2015.05.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2015.05.009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2015.05.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T20:12:13Z","timestamp":1759867933000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2015.05.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":175,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1016\/j.jalz.2015.05.009"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2015.05.009","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"2015-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}