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Thus, we combined available data on A\u03b2 levels and ratios, aggregation propensities, toxicities, and patient data for A\u03b2 variants and correlated these data to identify heterogeneity, significant relations, and basis for consensus. Despite heterogeneity, age of disease onset correlates to A\u03b2 levels (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.38, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018), but not to toxicities, A\u03b2<jats:sub>42<\/jats:sub> levels, A\u03b2<jats:sub>42<\/jats:sub>\/A\u03b2<jats:sub>40<\/jats:sub> ratios, or aggregation propensities. Cytotoxicity correlates inversely with total A\u03b2<jats:sub>42<\/jats:sub> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.65, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.016) and A\u03b2<jats:sub>42<\/jats:sub>\/A\u03b2<jats:sub>40<\/jats:sub> ratios (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.76, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005), i.e., chemical properties that increase A\u03b2<jats:sub>42<\/jats:sub> also reduce toxicity. The complexity and heterogeneity of data reveal the need to understand these phenotypes better, e.g., by focusing on the chemical properties of the involved A\u03b2 species.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.06.1895","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T05:33:00Z","timestamp":1438061580000},"page":"184-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["\u03b2\u2010Amyloid pathogenesis: Chemical properties versus cellular levels"],"prefix":"10.1002","volume":"12","author":[{"given":"Manish K.","family":"Tiwari","sequence":"first","affiliation":[{"name":"DTU Chemistry Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper P.","family":"Kepp","sequence":"additional","affiliation":[{"name":"DTU Chemistry Technical University of Denmark  Kongens Lyngby 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