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Analysis of the linked regions was repeated using the entire sample of 282 families. Validated chromosomal regions were analyzed using joint linkage and association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 26 regions linked to LOAD (HLOD \u22653.6). We validated 13 of the regions (HLOD \u22652.5) using the entire family sample. The strongest signal was at 11q12.3 (rs2232932: HLOD<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub>\u00a0=\u00a04.7, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>joint<\/jats:italic><\/jats:sub>\u00a0=\u00a06.6\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup>), a locus located \u223c2\u00a0Mb upstream of the membrane\u2010spanning 4A gene cluster. We additionally identified a locus at 7p14.3 (rs10255835: HLOD<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub>\u00a0=\u00a04.9, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>joint<\/jats:italic><\/jats:sub>\u00a0=\u00a01.2\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>), a region harboring genes associated with the nervous system (<jats:italic>GARS<\/jats:italic>, <jats:italic>GHRHR<\/jats:italic>, and <jats:italic>NEUROD6<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Future sequencing efforts should focus on these regions because they may harbor familial LOAD causative mutations.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.07.487","type":"journal-article","created":{"date-parts":[[2015,10,3]],"date-time":"2015-10-03T01:26:22Z","timestamp":1443835582000},"page":"1397-1406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"11","author":[{"given":"Sandra","family":"Barral","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University Medical Center  New York NY USA"},{"name":"Gertrude H. 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Hussman Institute for Human Genomics University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Beecham","sequence":"additional","affiliation":[{"name":"The John P. Hussman Institute for Human Genomics University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Cantwell","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Pericak\u2010Vance","sequence":"additional","affiliation":[{"name":"The John P. Hussman Institute for Human Genomics University of Miami  Miami FL USA"},{"name":"Dr. John T. 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