{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T21:26:39Z","timestamp":1771190799479,"version":"3.50.1"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T00:00:00Z","timestamp":1440806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG000333\u201007"],"award-info":[{"award-number":["AG000333\u201007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["108\/09"],"award-info":[{"award-number":["108\/09"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Blast traumatic brain injury (B\u2010TBI) affects military and civilian personnel. Presently, there are no approved drugs for blast brain injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Exendin\u20104 (Ex\u20104), administered subcutaneously, was evaluated as a pretreatment (48 hours) and postinjury treatment (2 hours) on neurodegeneration, behaviors, and gene expressions in a murine open field model of blast injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>B\u2010TBI induced neurodegeneration, changes in cognition, and genes expressions linked to dementia disorders. Ex\u20104, administered preinjury or postinjury, ameliorated B\u2010TBI\u2013induced neurodegeneration at 72 hours, memory deficits from days 7\u201314, and attenuated genes regulated by blast at day 14 postinjury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The present data suggest shared pathologic processes between concussive and B\u2010TBI, with end points amenable to beneficial therapeutic manipulation by Ex\u20104. B\u2010TBI\u2013induced dementia\u2010related gene pathways and cognitive deficits in mice somewhat parallel epidemiologic studies of Barnes et al. who identified a greater risk in US military veterans who experienced diverse TBIs, for dementia in later life.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.07.489","type":"journal-article","created":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T21:11:28Z","timestamp":1440882688000},"page":"34-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Blast traumatic brain injury\u2013induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon\u2010like peptide\u20101 receptor agonist, exendin\u20104"],"prefix":"10.1002","volume":"12","author":[{"given":"David","family":"Tweedie","sequence":"first","affiliation":[{"name":"Translational Gerontology Branch, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lital","family":"Rachmany","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vardit","family":"Rubovitch","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazhou","family":"Li","sequence":"additional","affiliation":[{"name":"Translational Gerontology Branch, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold W.","family":"Holloway","sequence":"additional","affiliation":[{"name":"Translational Gerontology Branch, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Lehrmann","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin G.","family":"Becker","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Perez","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry J.","family":"Hoffer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Case Western Reserve University School of Medicine  Cleveland OH USA"},{"name":"Graduate Program in Neuroregeneration Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaim G.","family":"Pick","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Sagol School of Neuroscience Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel H.","family":"Greig","sequence":"additional","affiliation":[{"name":"Translational Gerontology Branch, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0b013e31819581d8"},{"key":"e_1_2_7_3_1","volume-title":"How is deployment to Iraq and Afghanistan affecting U.S. service members and their families? An overview of early RAND research on the topic","author":"Hosek J","year":"2011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.06.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054163"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2011.08.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70164-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2010.09.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4981"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20104"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90162-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003716"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2004.tb00056.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021687810103"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-008-9094-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21160"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079837"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152711794653751"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720507781788873"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-45"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1886"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1332.018"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01971.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.01.008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.04.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2002-4605"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00160-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2165\/11635890-000000000-00000"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488910791213130"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21349"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00866.2010"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9464-0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.10.001"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082016"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.09.018"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.02.006"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1314"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032008"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.09.028"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02513-0"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.0891"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07377.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.01.021"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-6-144"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bat018"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01270"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05641.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01650-07"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023604"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.2174\/18715273113126660154"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008596"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.10.012"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04113.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20060691"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617708090036"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355478"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000616"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.2668"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062422"},{"key":"e_1_2_7_62_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.24101","article-title":"Traumatic brain injury and young onset dementia: A nationwide cohort study","volume":"75","author":"Nordstr\u03c6m P","year":"2014","journal-title":"Ann Neurol"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2690"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001358"},{"key":"e_1_2_7_65_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1017\/S1041610206003498","article-title":"Increased risk of dementia following mild head injury for carriers but not for non\u2010carriers of the APOE epsilon4 allele","volume":"19","author":"Sundstr\u03c6m A","year":"2007","journal-title":"Int Psychogeriatr"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302633"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303938"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2013-092758"},{"key":"e_1_2_7_69_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fneur.2013.00117","article-title":"Caveats for using shock tube in blast\u2010induced traumatic brain injury research","volume":"4","author":"Chen Y","year":"2013","journal-title":"Front Neurol"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.14429\/dsj.62.1149"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01163.x"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-140364"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68295"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103114"},{"key":"e_1_2_7_75_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1089\/neu.2013.2862","article-title":"Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast\u2010induced traumatic brain injury in rats","volume":"301","author":"Kochanek PM","year":"2013","journal-title":"J Neurotrauma"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2011.00019"},{"issue":"1","key":"e_1_2_7_77_1","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1016\/j.neuroimage.2010.05.031","article-title":"Mechanisms of blast induced brain injuries, experimental studies in rats","volume":"54","author":"Risling M","year":"2011","journal-title":"Neuroimage"},{"key":"e_1_2_7_78_1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1682\/JRRD.2011.09.0182","article-title":"Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures","volume":"49","author":"Valiyaveettil M","year":"2012","journal-title":"J Rehabil Res Dev"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.10.022"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617710000743"},{"key":"e_1_2_7_81_1","doi-asserted-by":"crossref","unstructured":"LiY BaderM TamargoI RubovitchV TweedieD PickCG et al.Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice.J Neurochem2015https:\/\/doi.org\/10.1111\/jnc.13169[Epub ahead of print]","DOI":"10.1111\/jnc.13169"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526015026667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526015026667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2015.07.489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2015.07.489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2015.07.489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2015.07.489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T19:48:07Z","timestamp":1759866487000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2015.07.489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,29]]},"references-count":80,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1016\/j.jalz.2015.07.489"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2015.07.489","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,29]]},"assertion":[{"value":"2015-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}