{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:40:07Z","timestamp":1792827607245,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#14002"],"award-info":[{"award-number":["#14002"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","award":["#WE.15\u20102013\u201008"],"award-info":[{"award-number":["#WE.15\u20102013\u201008"]}],"id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003132","name":"Agentschap voor Innovatie door Wetenschap en Technologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["#PI11\/02425#PI11\/00234"],"award-info":[{"award-number":["#PI11\/02425#PI11\/00234"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["#PI11\/03035"],"award-info":[{"award-number":["#PI11\/03035"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient\u2010acceptance of LP, incidence of and risk factors for post\u2010LP complications in memory clinic populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled 3868 patients (50% women, age 66\u00a0\u00b1\u00a011\u00a0years, mini mental state examination 25\u00a0\u00b1\u00a05) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post\u2010LP complications, such as typical postlumbar puncture headache (PLPH) and back pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1065 patients (31%) reported post\u2010LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age &gt;65\u00a0years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussions<\/jats:title><jats:p>The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.08.003","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T11:36:34Z","timestamp":1442057794000},"page":"154-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":241,"title":["Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study"],"prefix":"10.1002","volume":"12","author":[{"given":"Flora H.","family":"Duits","sequence":"first","affiliation":[{"name":"Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Martinez\u2010Lage","sequence":"additional","affiliation":[{"name":"Department of Neurology Fundacion CITA\u2010Alzheimer Fundazioa  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paquet","sequence":"additional","affiliation":[{"name":"INSERM, U942  Paris France"},{"name":"Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9, UMRS 942  Paris France"},{"name":"Research Memory Center Paris North AP\u2010HP Hopital Lariboisi\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Engelborghs","sequence":"additional","affiliation":[{"name":"Reference Center for Biological Markers of Dementia (BIODEM), Institute Born\u2010Bunge University of Antwerp  Antwerp Belgium"},{"name":"Department of Neurology and Memory Clinic Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[{"name":"Memory Unit Department of Neurology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Hausner","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Central Institute of Mental Health Medical Faculty Mannheim\/Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Molinuevo","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service ICN Hospital Clinic i Universitari and Pasqual Maragall Foundation  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Stomrud","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Farotti","sequence":"additional","affiliation":[{"name":"Centro Disturbi della Memoria, Clinica Neurologica Universit\u00e0 degli Studi di Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez H.G.B.","family":"Ramakers","sequence":"additional","affiliation":[{"name":"Alzheimer Center Limburg Department of Psychiatry &amp; NeuropsychologySchool for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Tsolaki","sequence":"additional","affiliation":[{"name":"3rd Department of Neurology Aristotle University of Thessaloniki  Macedonia Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Skarsg\u00e5rd","sequence":"additional","affiliation":[{"name":"The Department of Geriatrics Kalmar County Hospital  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnar","family":"\u00c5strand","sequence":"additional","affiliation":[{"name":"Department of Cognitive Medicine Karlstad Central Hospital  Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Wallin","sequence":"additional","affiliation":[{"name":"Memory Clinic at Department of NeuropsychiatrySahlgrenska University Hospital, Institute of Neuroscience and Physiology at Sahlgrenska Academy University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Vyhnalek","sequence":"additional","affiliation":[{"name":"Memory Clinic Department of Neurology, 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital  Prague Czech Republic"},{"name":"International Clinical Research Center St. Anne's University Hospital  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Holmber\u2010Clausen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Minnesmottagningen  Eskilstuna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestes V.","family":"Forlenza","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience (LIM\u201027), Department and Institute of Psychiatry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Pathophysiology and Transplantation University of Milan  Fondazione Ca' Grandam IRCCS Ospedale Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ingelsson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik I.","family":"Hoff","sequence":"additional","affiliation":[{"name":"Department of Neurology Atrium Medical Center Parkstad  Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerwin","family":"Roks","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Elisabeth Hospital  Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne M.","family":"Papma","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC\u2010University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Izagirre","sequence":"additional","affiliation":[{"name":"Department of Neurology Fundacion CITA\u2010Alzheimer Fundazioa  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Taga","sequence":"additional","affiliation":[{"name":"INSERM, U942  Paris France"},{"name":"Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9, UMRS 942  Paris France"},{"name":"Research Memory Center Paris North AP\u2010HP Hopital Lariboisi\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Struyfs","sequence":"additional","affiliation":[{"name":"Reference Center for Biological Markers of Dementia (BIODEM), Institute Born\u2010Bunge University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Alcolea","sequence":"additional","affiliation":[{"name":"Memory Unit Department of Neurology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Fr\u00f6lich","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Central Institute of Mental Health Medical Faculty Mannheim\/Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service ICN Hospital Clinic i Universitari and Pasqual Maragall Foundation  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Minthon","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos W.R.","family":"Twisk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"UCL Institute of Neurology Department of Molecular Neuroscience  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam VU University Medical Center  Amsterdam The Netherlands"},{"name":"Department of Epidemiology and Biostatistics VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory and Biobank Department of Clinical Chemistry, Neuroscience Campus Amsterdam VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.130518"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823ed0f0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03222.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.05.1753"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3233\/JAD-132672","article-title":"Who needs cerebrospinal biomarkers? A national survey in clinical practice","volume":"40","author":"Troussiere AC","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.02.004"},{"issue":"1","key":"e_1_2_7_12_1","article-title":"The international classification of headache disorders, 2nd edition","volume":"24","author":"The headache classification subcommittee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000194014.43575.fd"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131334"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000311703"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1993.tb03443.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1998.1809635.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10883"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1972.hed1202073.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.7.909"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2001.00200.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)80416-0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199004000-00008"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08753.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.10.1884"},{"key":"e_1_2_7_26_1","first-page":"CD009199","article-title":"Posture and fluids for preventing post\u2010dural puncture headache","volume":"7","author":"Arevalo\u2010Rodriguez I","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2014.07.004"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1989.0902099.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00556-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-196707000-00008"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526015027028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526015027028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2015.08.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2015.08.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2015.08.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2015.08.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T22:53:06Z","timestamp":1759877586000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2015.08.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,11]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1016\/j.jalz.2015.08.003"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2015.08.003","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,11]]},"assertion":[{"value":"2015-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}