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Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09\u20133.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29\u20134.18), but only in those who carried an apolipoprotein E (<jats:italic>APOE<\/jats:italic>) \u03b54 allele. IDSBP also predicted lower total brain volumes and more prevalent silent brain infarcts in those who were <jats:italic>APOE<\/jats:italic> \u03b54 positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were <jats:italic>APOE<\/jats:italic> \u03b54 positive.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.09.006","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T14:27:31Z","timestamp":1446647251000},"page":"438-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury"],"prefix":"10.1002","volume":"12","author":[{"given":"Matthew P.","family":"Pase","sequence":"first","affiliation":[{"name":"Boston University School of Medicine &amp; Framingham Heart Study  Boston MA USA"},{"name":"Centre for Human Psychopharmacology Swinburne University of Technology  Hawthorn Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa","family":"Beiser","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine &amp; Framingham Heart Study  Boston MA USA"},{"name":"Boston University School of Public Health  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine &amp; Framingham Heart Study  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine &amp; Imaging of Dementia and Aging Laboratory, Center for Neuroscience University of California Davis  Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine &amp; Framingham Heart Study  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Murabito","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine &amp; Framingham Heart Study  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine &amp; Framingham Heart Study  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70241-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a43e1c"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318227b227"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.10.1932"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.3.312"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrcardio.2012.92","article-title":"Cerebrovascular disease: Assessing the brain as an end\u2010organ of vascular disease","volume":"9","author":"Decarli C","year":"2012","journal-title":"Nat Rev Cardiol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.02.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.570044"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1002093"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61710-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X10384174"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828cf87c"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.10.027"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.41.3.279"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(75)90037-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1327"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.16.1939"},{"volume-title":"Diagnostic and Statistical Manual of Mental Disorders 4th ed. 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