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We observed no tolerability or toxicity issues in mice treated with R121919.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>CRFR1 antagonism presents a viable disease\u2010modifying therapy for AD, recommending its advancement to early\u2010phase human safety trials.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.09.007","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T17:15:30Z","timestamp":1446916530000},"page":"527-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Corticotropin\u2010releasing factor receptor\u20101 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Cheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla CA 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