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Immunoblotting and immunohistochemistry were used for validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the Braak stages, an altered expression was found for 372 proteins including changes in levels of extracellular matrix components, and in calcium\u2010dependent signaling proteins. Early changes were observed in levels of proteins related to cytoskeletal dynamics and synaptic components including an increase in RIMS1 and GRIK4. Several synaptic proteins, such as BSN, LIN7A, DLG2, \u20103, and \u20104, exhibit an early\u2010up, late\u2010down expression pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study provides new insight into AD\u2010dependent changes in protein levels in the hippocampus during AD pathology, identifying potential novel therapeutic targets and biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.11.002","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T19:26:31Z","timestamp":1452108391000},"page":"654-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease"],"prefix":"10.1002","volume":"12","author":[{"given":"David C.","family":"Hondius","sequence":"first","affiliation":[{"name":"Department of Pathology VU University Medical Center, Neuroscience 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