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A global measure of A\u03b2 burden was calculated, and composite scores assessing learning, delayed memory, and executive functioning were computed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher A\u03b2 was associated with classification of psychometric mild cognitive impairment (MCI) at follow\u2010up (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Linear mixed effects regression results indicated higher A\u03b2 was associated with greater rates of decline in delayed memory (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and executive functioning (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Apolipoprotein E (<jats:italic>APOE<\/jats:italic>) \u03b54 status moderated the relationship between A\u03b2 and cognitive trajectories (<jats:italic>P<\/jats:italic>\u00a0values &lt;.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In individuals at risk for AD, greater A\u03b2 in late middle age is associated with increased likelihood of MCI at follow\u2010up and steeper rates of cognitive decline.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2015.12.009","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T20:02:05Z","timestamp":1453406525000},"page":"805-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Beta\u2010amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study"],"prefix":"10.1002","volume":"12","author":[{"given":"Lindsay R.","family":"Clark","sequence":"first","affiliation":[{"name":"Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health  Madison WI USA"},{"name":"Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie M.","family":"Racine","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison WI USA"},{"name":"Institute on Aging University of Wisconsin\u2010Madison  Madison WI USA"},{"name":"Neuroscience and Public Policy Program University of Wisconsin\u2010Madison  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Koscik","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozioma C.","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health  Madison WI USA"},{"name":"Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison WI USA"},{"name":"Geriatric Research Education and Clinical Center Wm. 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