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There were significant associations between the rate of cognitive decline and decreased levels of Rab3 in DLB in the inferior parietal lobe and SNAP25 in AD in the prefrontal cortex. Of particular note, synaptic proteins significantly discriminated between dementia cases and controls with over 90% sensitivity and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings suggest that the proposition that synaptic markers can predict cognitive decline in AD, should be extended to Lewy body diseases.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2016.04.005","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T05:52:31Z","timestamp":1464069151000},"page":"1149-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Synaptic proteins predict cognitive decline in Alzheimer's disease and\u00a0Lewy body dementia"],"prefix":"10.1002","volume":"12","author":[{"given":"Erika","family":"Bereczki","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research 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