{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:23:28Z","timestamp":1792434208406,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T00:00:00Z","timestamp":1466208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005407","name":"Food and Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients surviving stroke without immediate dementia are at high risk of delayed\u2010onset dementia. Mechanisms underlying delayed\u2010onset dementia are complex and may involve vascular and\/or neurodegenerative diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dementia\u2010free patients with stroke and\/or transient ischemic attack (TIA; n\u00a0=\u00a0919) were studied for 3 years prospectively, excluding those who developed dementia 3 to 6\u00a0months after stroke and\/or TIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty subjects (4.4%) developed dementia during the study period. Imaging markers of severe small vessel disease (SVD), namely presence of \u22653 lacunes and confluent white matter changes; history of hypertension and diabetes mellitus independently predicted delayed\u2010onset dementia after adjustment for age, gender, and education. Only 6 of 31 (19.4%) subjects with delayed cognitive decline harbored Alzheimer's disease\u2013like Pittsburg compound B (PiB) retention. Most PiB cases (16\/25, 64%) had evidence of severe SVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Severe SVD contributes importantly to delayed\u2010onset dementia after stroke and\/or TIA. Future clinical trials aiming to prevent delayed\u2010onset dementia after stroke and\/or TIA should target this high\u2010risk group.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2016.05.007","type":"journal-article","created":{"date-parts":[[2016,6,19]],"date-time":"2016-06-19T22:26:49Z","timestamp":1466375209000},"page":"1167-1176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Delayed\u2010onset dementia after stroke or transient ischemic attack"],"prefix":"10.1002","volume":"12","author":[{"given":"Vincent C.T.","family":"Mok","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Therese Pei Fong Chow Research Centre for Prevention of Dementia  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie 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