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Genetic CJD cases showed increased CSF \u03b1\u2010synuclein values. No increased \u03b1\u2010synuclein levels were detected in non\u2010CJD cases with rapid progression course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Detection of \u03b1\u2010synuclein in the CSF of patients with suspected CJD is a valuable diagnostic test reaching almost full discrimination from non\u2010prion disease cases. These data highlight the utility of CSF \u03b1\u2010synuclein quantification in front of classical CSF biomarkers in clinical routine.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2016.09.013","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T13:16:47Z","timestamp":1479475007000},"page":"710-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Evaluation of \u03b1\u2010synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases"],"prefix":"10.1002","volume":"13","author":[{"given":"Franc","family":"Llorens","sequence":"first","affiliation":[{"name":"Department of Neurology, Clinical Dementia Center University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Site G\u00f6ttingen 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