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<jats:title>Introduction<\/jats:title>\n                    <jats:p>Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a transethnic genome\u2010wide association study (GWAS) for late\u2010onset AD in Stage 1 sample including whites of European Ancestry, African\u2010Americans, Japanese, and Israeli\u2010Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genome\u2010wide significant (GWS) associations in single\u2010nucleotide polymorphism (SNP)\u2013based tests (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a05 \u00d7 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      ) were identified for SNPs in\n                      <jats:italic>PFDN1\/HBEGF<\/jats:italic>\n                      ,\n                      <jats:italic>USP6NL\/ECHDC3<\/jats:italic>\n                      , and\n                      <jats:italic>BZRAP1\u2010AS1<\/jats:italic>\n                      and for the interaction of the (apolipoprotein E)\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 allele with\n                      <jats:italic>NFIC<\/jats:italic>\n                      SNP. We also obtained GWS evidence (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a02.7 \u00d7 10\n                      <jats:sup>\u22126<\/jats:sup>\n                      ) for gene\u2010based association in the total sample with a novel locus,\n                      <jats:italic>TPBG<\/jats:italic>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a01.8 \u00d7 10\n                      <jats:sup>\u22126<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2016.12.012","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T21:48:11Z","timestamp":1486417691000},"page":"727-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":199,"title":["Transethnic genome\u2010wide scan identifies novel Alzheimer's disease loci"],"prefix":"10.1002","volume":"13","author":[{"given":"Gyungah R.","family":"Jun","sequence":"first","affiliation":[{"name":"Neurogenetics and Integrated Genomics Andover Innovative Medicines Institute, Eisai Inc  Andover MA USA"},{"name":"Department of Medicine (Biomedical Genetics) Boston University Schools of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeyoon","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medicine (Biomedical Genetics) Boston University Schools of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Mez","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Schools of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Neuroscience University of North Texas Health Science Center  Fort Worth TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Beecham","sequence":"additional","affiliation":[{"name":"The John P. 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