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In recent years, the development of highly sensitive mass spectrometry platforms and other high\u2010throughput technologies has enabled the discovery of complex changes in the entire lipidome. This lipidomics approach promises to be a particularly useful tool for identifying diagnostic biomarkers for early detection of age\u2010related neurodegenerative disease, such as Alzheimer's disease (AD), which has till recently been limited to protein\u2010 and gene\u2010centric approaches. This review highlights known lipid changes affecting the AD brain and presents an update on the progress of lipid biomarker research in AD. 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