{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:11:40Z","timestamp":1759968700836,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T00:00:00Z","timestamp":1487376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Findings for genetic correlates of late\u2010onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated previously identified LOAD\u2010risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in\u2010home and clinic visits (<jats:italic>n<\/jats:italic>\u00a0=\u00a01697) to HRs estimated using only data that were obtained from clinic visits (<jats:italic>n<\/jats:italic>\u00a0=\u00a01308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LOAD associations nominally differed for 4 of 21 variants; <jats:italic>CR1<\/jats:italic> and <jats:italic>APOE<\/jats:italic> variants were significant after Bonferroni correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Estimates of genetic associations may differ for studies limited to clinic\u2010only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2017.01.012","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T06:30:14Z","timestamp":1487658614000},"page":"933-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of home visit capacity on genetic association studies of late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"13","author":[{"given":"David W.","family":"Fardo","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Sanders\u2010Brown Center on Aging University of Kentucky  Lexington KY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubhabrata","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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