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We performed functional validation on novel genes using a transgenic\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                      A\u03b2 proteotoxicity model and evaluated novel genes using brain expression data from people with LOAD and other neurodegenerative conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 13 novel candidate LOAD genes outside chromosome 19. Of those, RNA interference knockdowns of the\n                      <jats:italic>C. elegans<\/jats:italic>\n                      orthologs of\n                      <jats:italic>UBC, NDUFS3, EGR1<\/jats:italic>\n                      , and\n                      <jats:italic>ATP5H<\/jats:italic>\n                      were associated with A\u03b2 toxicity, and\n                      <jats:italic>NDUFS3, SLC25A11, ATP5H<\/jats:italic>\n                      , and\n                      <jats:italic>APP<\/jats:italic>\n                      were differentially expressed in the temporal cortex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Network analyses identified novel LOAD candidate genes. We demonstrated a functional role for four of these in a\n                      <jats:italic>C. elegans<\/jats:italic>\n                      model and found enrichment of differentially expressed genes in the temporal cortex.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2017.01.016","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T21:00:15Z","timestamp":1487970015000},"page":"1133-1142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Systems biology approach to late\u2010onset Alzheimer's disease genome\u2010wide association study identifies novel candidate genes validated using brain expression data and\n                    <i>Caenorhabditis elegans<\/i>\n                    experiments"],"prefix":"10.1002","volume":"13","author":[{"given":"Shubhabrata","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariet","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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