{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:53:12Z","timestamp":1787953992172,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["09-063599"],"award-info":[{"award-number":["09-063599"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["09-069151"],"award-info":[{"award-number":["09-069151"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a 44\u2010year follow\u2010up, 6416 (0.96%) men developed dementia, 1760 (0.26%) and 970 (0.15%) of which were classified as Alzheimer's and vascular dementia, respectively. Low cognitive ability was associated with increased risk of dementia (hazard ratio [HR]<jats:sub>per SD decrease<\/jats:sub> 1.33 [95% confidence interval {CI}\u00a0=\u00a01.30\u20131.35]) with the strongest associations for vascular dementia (HR<jats:sub>per\u00a0SD decrease<\/jats:sub> 1.47 [95% CI\u00a0=\u00a01.31\u20131.56]) and a weaker for Alzheimer's disease (HR<jats:sub>per SD decrease<\/jats:sub> 1.07 [95% CI\u00a0=\u00a01.03\u20131.13]). The intrabrother and twin analyses (taking shared family factors into account) showed attenuated risk estimates but with wide CIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Low early\u2010life cognitive ability increases the risk of dementia before the age of 78 years. The association is partly explained by shared family factors.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2017.04.003","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T16:52:44Z","timestamp":1495212764000},"page":"1355-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins"],"prefix":"10.1002","volume":"13","author":[{"given":"Merete","family":"Osler","sequence":"first","affiliation":[{"name":"Research Center for Prevention and Health, Rigshospitalet\u2010Glostrup University of Copenhagen  Glostrup Denmark"},{"name":"Department of Public Health University of Copenhagen  Denmark"},{"name":"Department of Public Health, Danish Aging Research Center University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild 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